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CAS:932986-18-0|N-(2-(2-(4-氯苯基)噻唑-4-基)乙基)丁酰胺
作者：德尔塔 日期：2022-03-25
产品名称 N-(2-(2-(4-氯苯基)噻唑-4-基)乙基)丁酰胺 英文名称 Azoramide 规格或纯度 98% 别名 N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide 英文别名 N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide 运输条件 常规运输 生化机理 未折叠蛋白应答（UPR）的调节剂。通过改善ER蛋白的折叠和激活ER分子伴侣的能力来保护细胞免受ER胁迫。还可以改善ER钙保留。在小鼠肥胖模型中改善肝脏ER功能，葡萄糖稳态和葡萄糖刺激的胰岛素分泌。口服具有生物活性。CAS编号 932986-18-0
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CAS:14003-96-4|4μ8C
作者：德尔塔 日期：2022-03-25
产品名称 4μ8C 英文名称 4μ8C 规格或纯度 98% (HPLC) 别名 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde 英文别名 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde 运输条件 超低温冰袋运输 生化机理 阻止底物进入IRE1α的活性位点。响应内吞性网状结构（ER）应激，抑制IRE1依赖性降解（RIDD）和Xbp1 mRNA的非常规加标，但对IRE1激酶活性没有影响。CAS编号 14003-96-4
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CAS:1337531-36-8|GSK2606414
作者：德尔塔 日期：2022-03-25
产品名称 GSK2606414 英文名称 GSK2606414 规格或纯度 ≥98% 别名 GSK 2606414;GSK-2606414 英文别名 GSK 2606414;GSK-2606414;7-Methyl-5-[1-[[3-(trifluoromethyl)phenyl]acetyl]-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 运输条件 超低温冰袋运输 生化机理 有力和选择性的蛋白激酶R样ER激酶（PERK）抑制剂（IC50 = 0.4 nM）。与HR1和PKR相比，PERK具有> 1000倍的选择性。抑制thapsigargin诱导的肺癌A549细胞中的PERK磷酸化。减轻小鼠中皮下胰腺人类肿瘤异种移植物的生长。口服具有生物活性。CAS编号 1337531-36-8
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CAS:244767-67-7|Dapivirine (TMC120)
作者：德尔塔 日期：2022-03-25
产品名称 Dapivirine (TMC120) 英文名称 Dapivirine (TMC120) 规格或纯度 ≥98% 别名 R 147681; TMC 120CAS编号 244767-67-7 溶解性 DMSO 34 mg/mL Water
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CAS:69123-90-6|Fiacitabine
作者：德尔塔 日期：2022-03-25
产品名称 Fiacitabine 英文名称 Fiacitabine 生化机理 Fiacitabine(NSC 382097; FIAC; FOAC) is useful for treatment of tumors or viral infections.CAS编号 69123-90-6 溶解性 DMSO 储存温度 储存温度-20°C
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CAS:697761-98-1|Elvitegravir(GS-9137,JTK-303)
作者：德尔塔 日期：2022-03-25
产品名称 Elvitegravir(GS-9137,JTK-303) 英文名称 Elvitegravir (GS-9137, JTK-303) 应用 An HIV-1 integrase inhibitor 规格或纯度 ≥99% 别名 埃替拉韦 英文别名 GS-9137; JTK-303; EVG; D06677;6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 运输条件 冰袋运输 生化机理 Elvitegravir is an inhibitor of HIV-1 integ
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CAS:1051375-16-6|Dolutegravir (GSK1349572)
作者：德尔塔 日期：2022-03-25
产品名称 Dolutegravir (GSK1349572) 英文名称 Dolutegravir (GSK1349572) 应用 Dolutegravir (GSK1349572)是一种HIV整合酶抑制剂，IC50为2.7 nM，适度有效作用于抗Raltegravir的显著突变体Y143R， Q148K， N155H，和G140S/Q148H。 规格或纯度 ≥99% 别名 GSK1349572;度鲁特韦 英文别名 Dolutegravir;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- 运输条件 超低温冰袋运输
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CAS:136817-59-9|Delavirdine
作者：德尔塔 日期：2022-03-25
产品名称 Delafloxacin 英文名称 Delafloxacin 规格或纯度 ≥98% 别名 RX-3341;WQ-3034;ABT492 生化机理 Description:IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1]ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms.in vitro: ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015 [2]. ABT-492 was as active as trovafloxa
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CAS:189279-58-1|Delafloxacin
作者：德尔塔 日期：2022-03-25
产品名称 Delafloxacin 英文名称 Delafloxacin 规格或纯度 ≥98% 别名 RX-3341;WQ-3034;ABT492 生化机理 Description:IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1]ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms.in vitro: ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015 [2]. ABT-492 was as active as trovafloxa
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CAS:473921-12-9|Lersivirine
作者：德尔塔 日期：2022-03-25
产品名称 Lersivirine 英文名称 Lersivirine 生化机理 Lersivirine (UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for the treatment of HIV-1 infection. Lersivirine prevents HIV from entering the nucleus of healthy CD4 cells. This prevents the cells from producing new virus and decreases the amount of virus in the body. Lersivirine, a weak inducer of the cytochrome P450 (CYP) enzyme CYP3A4, is metabolized by CYP3A4 and UDP glucuronosyltransferase 2B7 (UGT2B7).CAS编号 473921-12-9 溶解性 DMSO
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CAS:917389-32-3|Letermovir
作者：德尔塔 日期：2022-03-25
产品名称 BMS-707035 英文名称 BMS-707035 规格或纯度 ≥98% 别名 BMS-707035, HIV-I integrase (IN) inhibitor 英文别名 BMS-707035, HIV-I integrase (IN) inhibitor 运输条件 超低温冰袋运输 生化机理 BMS-707035 is an HIV-1 integrase (IN) inhibitor. BMS-707035 was scheduled to be evaluated in a Phase II study to assess the antiretroviral activity, safety, pharmacodynamics, and pharmacokinetics in 50 HIV-infected subjects using a 10-day randomized, double-blind, placebo-controlled, ascending multiple-dose study design.Po
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CAS:729607-74-3|BMS-707035
作者：德尔塔 日期：2022-03-25
产品名称 BMS-707035 英文名称 BMS-707035 规格或纯度 ≥98% 别名 BMS-707035, HIV-I integrase (IN) inhibitor 英文别名 BMS-707035, HIV-I integrase (IN) inhibitor 运输条件 超低温冰袋运输 生化机理 BMS-707035 is an HIV-1 integrase (IN) inhibitor. BMS-707035 was scheduled to be evaluated in a Phase II study to assess the antiretroviral activity, safety, pharmacodynamics, and pharmacokinetics in 50 HIV-infected subjects using a 10-day randomized, double-blind, placebo-controlled, ascending multiple-dose study design.Po
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CAS:1200133-34-1|VCH-916
作者：德尔塔 日期：2022-03-25
产品名称 Abacavir sulfate 英文名称 Abacavir sulfate 应用 A nucleoside reverse transcriptase inhibitor. 规格或纯度 ≥99% 别名 硫酸阿巴卡韦 英文别名 1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate; ABC; Abacavir Hemisulfate 运输条件 冰袋运输 生化机理 Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine anal
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CAS:188062-50-2|Abacavir sulfate
作者：德尔塔 日期：2022-03-25
产品名称 Abacavir sulfate 英文名称 Abacavir sulfate 应用 A nucleoside reverse transcriptase inhibitor. 规格或纯度 ≥99% 别名 硫酸阿巴卡韦 英文别名 1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate; ABC; Abacavir Hemisulfate 运输条件 冰袋运输 生化机理 Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine anal
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CAS:869901-69-9|MK-2048
作者：德尔塔 日期：2022-03-25
产品名称 Amadacycline 英文名称 Amadacycline 规格或纯度 98% 别名 奥玛环素 英文别名 PTK 0796 运输条件 超低温冰袋运输 生化机理 Description: IC50 Value: N/A Amadacyclin is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome. in vitro: in vivo: Clinical trial: Phase III Study to Compare the Safety and Efficacy of PTK-0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI).CAS编号 389139-89-3
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