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Suberic acid-d12，Octanedioic acid-d12「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Suberic acid-d12 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Suberic acid-d12 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：186.27Formula：C8H2D12O4CAS 号：169397-99-3性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 98.60%参考文献[1]. Russak EM, et al. Impact of Deuter
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4-(Trifluoromethylbenzoic acid-13C6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：4-(Trifluoromethyl)benzoic acid-13C6 is the 13C labeled 4-(Trifluoromethyl)benzoic acid[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：196.08Formula：C213C6H5F3O2CAS 号：2731552-41-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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4-Bromobenzaldehyde-13C6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：4-Bromobenzaldehyde-13C6 is the 13C labeled 4-Bromobenzaldehyde[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：190.97Formula：C13C6H5BrOCAS 号：1037620-59-9非标记 CAS：1122-91-4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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1,3-Diphenylurea-d10，sym-Diphenylurea-d10「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：1,3-Diphenylurea-d10 is the deuterium labeled 1,3-Diphenylurea[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：222.31Formula：C13H2D10N2OCAS 号：108009-46-7非标记 CAS：102-07-8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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Carbamazepine 10,11-epoxide-13C,d2「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Carbamazepine 10,11-epoxide-13C,d2 is the deuterium labeled Carbamazepine 10,11-epoxide-C13. Carbamazepine 10,11-epoxide-C13 is a 13C-labled Carbamazepine 10,11-epoxide. Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Carbamazepine 10,11-epoxide-13C,d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：255.27Formula：C1413CH10D2N2O2CAS 号：1189497-48-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store
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Thiorphan-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：260.36Formula：C12H8D7NO3SCAS 号：1276297-68-7非标记 CAS：76721-89-6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6. [Content Brief]
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(2R-3-(((2-Aminoethoxy(hydroxyphosphoryloxypropane-1,2-diyl ditetradecanoate-d54「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d54 is deuterium labeled (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate. (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d54 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：690.19Formula：C33H12D54NO8PCAS 号：326495-41-4性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80
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2-Amino-2-methyl-1-propanol-d11，2-氨基-2-甲基-1-丙醇-d11「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：2-Amino-2-methyl-1-propanol-d11 is the deuterium labeled 2-Amino-2-methyl-1-propanol[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：100.20Formula：C4D11NOCAS 号：1435933-80-4中文名称：2-氨基-2-甲基-1-丙醇-d11运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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Isovaleric acid-d2「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Isovaleric acid-d2 is the deuterium labeled Isovaleric acid[1]. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Isovaleric acid-d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：104.14Formula：C5H8D2O2CAS 号：95927-02-9非标记 CAS：503-74-2性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.49%参考文献[1]. Russak EM, et al. Impa
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p-Tolualdehyde-d4，对甲基苯甲醛-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：p-Tolualdehyde-d4 is the deuterium labeled p-Tolualdehyde[1]. p-Tolualdehyde is an endogenous metabolite.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.p-Tolualdehyde-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：124.17Formula：C8H4D4OCAS 号：1219804-07-5中文名称：对甲基苯甲醛-d4； 4-甲基苯甲醛-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (522 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceutical
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2,4-D-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：2,4-D-d3 is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2,4-D-d3 相关抗体:Ctip2 AntibodyRb AntibodyPhospho-Rb (Ser807) AntibodyRPA32 Antibody (YA679)CDT1 AntibodyDNA-PKcs/PRKDC AntibodyHes1 AntibodyJunB AntibodyLIN28A AntibodyLin28B AntibodyMCM2 AntibodyNanog AntibodyNucleolin AntibodyPCNA AntibodyPDX1 AntibodyRbBP5 AntibodyS100A4 AntibodySP1 AntibodyBRCA1 Antibody (YA819)Argonaute 2 AntibodyBRCA1 AntibodyElongation Factor 1A1 AntibodyKAP1 AntibodyMCM2 Antibody (YA705)MLH1 Antibody (YA703)RNA Polymerase II Subunit B1 AntibodyRPA70 Antibody (YA678)SP7/Osterix AntibodyDNA PKcs Antibody (YA957)DNA PKcs Antibody (YA959)分子量：224.06Formula：C8H3D3Cl2O3CAS 号：202480-67-9非标记 CAS：94-75-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
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Diflunisal-d3，二氟尼柳-d3; MK-647-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Diflunisal-d3 is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Diflunisal-d3 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：253.22Formula：C13H5D3F2O3CAS 号：1286107-99-0非标记 CAS：22494-42-4中文名称：二氟尼柳-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Lin JH, et al. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. J Pharmacol Exp Ther. 1985 Nov;235(2):402-6. [Content Brief][3]. Winter CA, et a
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Valsartan-d8，CGP 48933-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Valsartan-d8 is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Valsartan-d8 相关抗体:Natriuretic Peptides A Antibody (YA1381)Angiotensinogen Antibody (YA2097)Natriuretic Peptides B Antibody (YA999)Natriuretic Peptides B Antibody (YA1000)Natriuretic Peptides B Antibody (YA1001)AGTR2 Antibody (YA3090)Angiotensin II Type 1 Receptor Antibody (YA3358)分子量：443.57Formula：C24H21D8N5O3CAS 号：1089736-72-0非标记 CAS：137862-53-4性状：固体颜色：White to off-white中文名称：缬沙坦 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Quercetin-d5，槲皮素 d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Quercetin-d5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].分子量：307.27Formula：C15H5D5O7CAS 号：263711-78-0非标记 CAS：117-39-5中文名称：槲皮素 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [Content Brief]
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Sparsentan-d5，RE-021-d5; DARA-a-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sparsentan-d5 相关抗体:Natriuretic Peptides A Antibody (YA1381)Angiotensinogen Antibody (YA2097)Natriuretic Peptides B Antibody (YA999)Natriuretic Peptides B Antibody (YA1000)Natriuretic Peptides B Antibody (YA1001)AGTR2 Antibody (YA3090)Endothelin Receptor B Antibody (YA3255)Angiotensin II Type 1 Receptor Antibody (YA3358)分子量：597.78Formula：C32H35D5N4O5SCAS 号：1801597-09-0非标记 CAS：254740-64-2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (533 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J
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