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CAS:1135-24-6|阿魏酸
作者：德尔塔 日期：2022-03-15
产品名称 阿魏酸 英文名称 Ferulic acid 规格或纯度 分析标准品,≥99.5%（HPLC） 别名 4-羟基-3-甲氧基肉桂酸 英文别名 3-(4-hydroxy-3-methoxyphenyl)-2-Propenoic acid 4-Hydroxy-3-methoxycinnamic acid 运输条件 常规运输 生化机理 羟基肉桂酸。在植物细胞壁成分中发现丰富的酚类植物化学成分。在体外和体内的抗氧化作用。CAS编号 1135-24-6 敏感性 对湿度敏感
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CAS:1135-24-6|阿魏酸
作者：德尔塔 日期：2022-03-15
产品名称 阿魏酸 英文名称 Ferulic acid 规格或纯度 99% 别名 4-羟基-3-甲氧基肉桂酸 英文别名 3-(4-hydroxy-3-methoxyphenyl)-2-Propenoic acid 4-Hydroxy-3-methoxycinnamic acidCAS编号 1135-24-6 敏感性 对湿度敏感 比旋光度 折光率
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CAS:341031-54-7|Sunitinib Malate
作者：德尔塔 日期：2022-03-15
产品名称 Sunitinib Malate 英文名称 Sunitinib Malate 应用 苹果酸舒尼替尼属于多靶点酪氨酸激酶抑制剂。 规格或纯度 ≥99% 别名 苹果酸苏尼替尼 英文别名 SU-11248;N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate 运输条件 超低温冰袋运输 生化机理 ATP竞争性有效的VEGFR，PDGFRβ和KIT抑制剂（VEG
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CAS:183319-69-9|Erlotinib HCl (OSI-744)
作者：德尔塔 日期：2022-03-15
产品名称 Erlotinib HCl (OSI-744) 英文名称 Erlotinib HCl (OSI-744) 应用 A HER-1/EGFR tyrosine kinase inhibitor 规格或纯度 ≥99% 别名 盐酸埃罗替尼；774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐 英文别名 Tarceva; CP-358774; OSI-774; NSC 718781;N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride 运输条件 超低温冰袋运输 生
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CAS:1058137-23-7|德立替尼
作者：德尔塔 日期：2022-03-15
产品名称 德立替尼 英文名称 E-3810 规格或纯度 98% 英文别名 E 3810;E3810;6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide 运输条件 超低温冰袋运输 生化机理 E-3810, a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.CAS编
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CAS:183321-74-6|Erlotinib
作者：德尔塔 日期：2022-03-15
产品名称 Erlotinib 英文名称 Erlotinib 应用 A tyrosine kinase inhibitor 规格或纯度 ≥98% 别名 R 1415;埃罗替尼 英文别名 NSC 718781;OSI-744;R-1415;OSI744;OSI 744;R1415;R 1415;N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; Tarceva 运输条件 超低温冰袋运输 生化机理 Erlotinib hydrochloride (trade name Ta
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CAS:917879-39-1|MK-2461
作者：德尔塔 日期：2022-03-15
产品名称 MK-2461 英文名称 MK-2461 规格或纯度 ≥99%CAS编号 917879-39-1 敏感性 比旋光度 折光率 凝固点 沸点 溶解性 DMSO
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CAS:857876-30-3|Motesanib Diphosphate (AMG-706)
作者：德尔塔 日期：2022-03-15
产品名称 Motesanib Diphosphate (AMG-706) 英文名称 Motesanib Diphosphate (AMG-706) 应用 An ATP-competitive inhibitor. 规格或纯度 ≥98% 别名 二磷酸莫替沙尼;AMG 706 生化机理 Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM and 59 nM, respectively.CAS编号 857876-30-3
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CAS:183320-51-6|OSI-420
作者：德尔塔 日期：2022-03-15
产品名称 OSI-420 英文名称 OSI-420 规格或纯度 ≥99% 生化机理 OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.CAS编号 183320-51-6 敏感性 比旋光度 折光率
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CAS:343787-29-1|CP-673451
作者：德尔塔 日期：2022-03-15
产品名称 CP-673451 英文名称 CP-673451 规格或纯度 ≥98% 别名 CP 673451;CP673451 英文别名 CP 673451; CP673451;1-[2-[5-(2-methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine 运输条件 超低温冰袋运输 生化机理 有效和选择性的PDGFR抑制剂（PDGFR-α和β的IC50值分别为1和10 nM）。在一系列相关激酶中对PDGFR激酶具有选择性。胶质母细胞瘤异种移植物中的PDGFR-β磷酸化异常和PDGF诱导的小鼠血管生成。CAS编号 343787-29-1
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CAS:1374640-70-6|CO-1686(AVL-301)
作者：德尔塔 日期：2022-03-15
产品名称 CO-1686(AVL-301) 英文名称 CO-1686 (AVL-301) 规格或纯度 ≥99% 生化机理 Description:IC50 Value: 21.5±1.7 nM (EGFRL858R/T790M); 303.3 ± 26.7 nM (EGFRWT) [1]CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M while exhibiting minimal activity towards the wild-type (WT) receptor.in vitro: CO-1686 is a potent inhibitor of EGFR L858R/T790M kinase (kinact/Ki = (2.41 ± 0.30) x 105 M-1s-1) and is approximately 22-fold selective over WT EGFR (kinactt/Ki = (1.12 ± 0.14) x 104 M-1s-1). CO-1686 potently inhibited proliferation in the mutant-EGFR NSCLC cellswith GI50 values ranging from 7 - 32 nM. In comparison, the GI50 value for A431 cells, an epidermoid cell line that is driven by amplified WT EGFR(19), was 547 nM. Two cell linesexpressing WT EGFR in the presence of an N- or KRAS mutation (NCI-H1299 and NCI-H358,respectively) were inhibited by CO-1686 at a concentration of 4275 and 1806 nM, respectively [1].CAS编号 1374640-70-6
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CAS:1206799-15-6|LY2801653
作者：德尔塔 日期：2022-03-15
产品名称 LY2801653 英文名称 LY2801653 规格或纯度 98% 英文别名 LY-2801653;LY 2801653；N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide；Merestinib 运输条件 超低温冰袋运输 生化机理 Description: IC50 Value: 2 nM(Ki value) LY2801653 is a potent, orally bioavailable, small-molecule inhibitorLY2801653 targeting MET kinase. in vitro: LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AX
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CAS:1254473-64-7|LY2874455
作者：德尔塔 日期：2022-03-15
产品名称 LY2874455 英文名称 LY2874455 规格或纯度 ≥99% 别名 LY 2874455; LY-2874455;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol 英文别名 LY 2874455; LY-2874455;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol 运输条件 超低温冰袋运输 生化机理 LY2874455 is a novel and potent FGF/FGFR Inhibitor. LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several t
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CAS:388082-77-7|二对甲苯磺酸拉帕替尼(GW-572016)
作者：德尔塔 日期：2022-03-15
产品名称 二对甲苯磺酸拉帕替尼(GW-572016) 英文名称 Lapatinib Ditosylate (GW-572016) 规格或纯度 ≥98% 别名 GW-572016 生化机理 Lapatinib ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. ErbB-2 and EGFR dual tyrosine kinases are growth promoting factors that are over expressed in some breast cancer cell lines. Research studies have reported that Lapatinib Ditosylate can inhibit breast cancer cell proliferation.CAS编号 388082-77-7 溶解性
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CAS:796967-16-3|Linifanib (ABT-869)
作者：德尔塔 日期：2022-03-15
产品名称 Linifanib (ABT-869) 英文名称 Linifanib (ABT-869) 应用 A VEGF (Flk/Flt) and PDGFR inhibitor. 规格或纯度 ≥99% 生化机理 ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (Flt/Flk) and PDGFR families (e.g., KDR, Flt1, Flt3, Flt4, CSF-1R, and KIT) demonstrating IC50 values ranging from 4-190 nM. ABT-869 shows little activity against unrelated RTKs, cytoplasmic tyrosine kinases, or Ser/Thr kinases (IC50 > 1 μM). ABT-869 inhibits proliferation in MV-4-11 and MOLM-13 cells (acute myeloid leukemia cell lines harboring RTK mutations; IC50 = 4 and 6 nM, respectively), inducing apoptosis as evidenced by an increased sub-G0/G1 phase cell population, caspase activation, and PARP cleavage. In murine xenograft models, as well as in a phase 1 clinical trial, ABT-869 demonstrated respectable efficacy
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