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Cy7 maleimide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of cysteine residues, as well as other thiolated moleculesCy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. Labeled proteins thus obtained are used in NIR bioimaging applications. In tissues or in live organism, NIR imaging systems can be used to visualize distribution of labeled proteins. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In splenocytes, for ease of detection, P22 particles were labeled internally with Cy7-maleimide. P22-Cy7 alone or P22-Cy7 decorated with DecSelf was incubated with splenocytes at 37℃ to encourage phagocytosis [1].Reference:[1]. Schwarz, B.; Madden, P.; Avera, J.; Gordon, B.; Larson, K.; Miettinen, H.; Uchida, M.; LaFrance, B.; Basu, G.; Rynda-Apple, A.; Douglas, T. Symmetry Controlled, Genetic Presentation of Bio-Active Proteins on the P22 Virus-Like Particle Using an External Decoration Protein. ACS Nano, 2015, 9(9), 9134–9147.Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. Labeled proteins thus obtained are used in NIR bioimaging applications. In tissues or in live organism, NIR imaging systems can be used to visualize distribution of labeled proteins. For biomole
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Cy7 DiC18
作者：德尔塔 日期：2022-09-26
Cy7 DiC18 是一种亲脂、近红外荧光氰化物染料，用于膜染色。Cy7 DiC18 is a lipophilic, near-infrared fluorescent cyanine dye used for staining membranes.Cy7 DiC18 is a lipophilic, near-infrared fluorescent cyanine dye used for staining membranes.Cas No. 100068-60-8 SDF 别名 N/A 化学名 N/A Canonical SMILES CCCCCCCCCCCCCCCCCC[N+]1=C(/C=C/C=C/C=C/C=C2N(CCCCCCCCCCCCCCCCCC)C3=C(C=CC=C3)C/2(C)C)C(C)(C)C4=C1C=CC=C4.[I-] 分子式 C63H101IN2 分子量 1013.39 溶解度 Soluble in DMSO 储存条件 4°C, protect from light General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy7 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy7 carboxylic acid is a near-infrared fluorescent dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cy7, together with carboxylic acid (CA) make up the model drugs. On the basis of this, the study was able to estimate the amount of Cy7 carboxylic acid on the particle through direct emission spectra measurements [1].Reference:[1] Zhao, Y. ; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bjrky, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature Communications, 2016,7,11221.Cy7 carboxylic acid is a near-infrared fluorescent dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of
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Cy7 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesCy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecules is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. This product can be used for the incorporation of Cy7 azide into various biomolecules and post-synthetic modification of oligonucleotides is also available. PEG-b-PPLG-Cy7 was conjugated by Cy7 azid and the polymer of PEG-b-PPLG. In blank micelles, it was used to probe the association of unimers [1].Reference:[1] Morton, S. W.; Zhao, X.; Quadir, M.A.; Hammond, P.T. FRET-enabled biological characterization of polymeric micelles. Biomaterials,2014, 35(11), 3489-3496.Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecules is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. This product can be used for the incorporation of Cy7 azide into various biomolecules and post-synthetic modification of oligonucleotides is also a
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CY7
作者：德尔塔 日期：2022-09-26
Cy7 (Sulfo-Cyanine7) 是一种荧光标记试剂 (Ex=750 nm，Em=773 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽，寡聚核苷酸等。Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides[1].[1]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides[1].[1]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cas No. 943298-08-6 SDF 别名 N/A 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(O)=O)=C\C=C\C=C\C=C\C2=[N+](CC)C(C=CC(S(=O)([O-])=O)=C3)=C3C2(C)C)(C)C4=C1C=CC(S(=O)(O)=O)=C4 分子式 C35H42N2O8S2 分子量 682.85 溶解度 DMSO: ≥ 33 mg/mL (48.33 mM) 储存条件 Store at -20°C
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Cy5.5-SE
作者：德尔塔 日期：2022-09-26
Cy5.5-SE 是一种花青染料，可标记多肽、蛋白和寡核苷酸中的氨基。Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cas No. 442912-55-2 SDF 别名 N/A 化学名 N/A Canonical SMILES O=S(C1=CC(S(=O)([O-])=O)=C2C(C3=C([N+](CC)=C(/C=C/C=C/C=C4N(CCCCCC(ON5C(CCC5=O)=O)=O)C6=C(C7=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C7C=C6)C/4(C)C)C3(C)C)C=C2)=C1)(O)=O 分子式 C45H47N3O16S4 分子量 1014.13 溶解度 Soluble in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5.5 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Cy5.5-NHS ester is a near-infrared amine reactive dye for labeling amino groups of peptides, proteins and oligonucleotides.Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) }); Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) });Cell experiment [1]:Cell lines U87MGPreparation Method U87MG cells (1 ×
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Cy5.5 hydrazide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
carbonyl-reactive dyeCy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers. Glycoproteins also can be labeled after periodate oxidation to form aldehyde groups. Therefore, this dye is especially applicable for the labeling of antibody. Moreover, Cy5.5 is a near infrared fluorophore with prominent ability of tissue penetration, so it is suitable for the applications which require low fluorescence background, and for the in vivo NIR imaging. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.Cy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers.
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Cy5.5 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α-CD hydrogel in vivo [1].Reference:[1] Wang, X. ; Wang, C.; Zhang, Q.; Cheng, Y. Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery. Chemical Communications, 2016, 52, 978–981.Cy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α
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Cy5.5 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesThis Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In human glioblastoma U87MG cells, to assess the capability of the Cu(I)/M-dots for cell labeling Cy5.5-azide was in combination with Cu(I)/M-dots for imaging of the integrin αⅤβ3 receptor [1].Reference:[1] Sun, Y. ; Hong, S.; Ma, X.; Cheng, K.; Wang, J.; Zhang, Z.; Yang, M.; Jiang, Y.; Hong, X.; Cheng, Z. Recyclable Cu(I)/Melanin Dots for Cycloadditions, Bioconjugation and Cell Labeling. Chemical Science.This Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is nec
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Cy5.5 alkyne (non-sulfonated)
作者：德尔塔 日期：2022-09-26
远红外/近红外染料，用于点击化学标记Cy5.5 alkyne (non-sulfonated)是一种远红外/近红外染料炔，含有乙炔基，用于点击化学标记。Cyanine5.5是Cy5.5®的类似物，Cy5.5®是一种常见的荧光团，被广泛用于各种应用，包括完整的生物体成像。Cy5.5 alkyne (non-sulfonated)在温和铜催化的点击化学条件下可以与叠氮基团结合。Cy5.5 alkyne (non-sulfonated)可溶于有机溶剂，但水与小百分比的DMSO混合物可用于有效的缀合反应。Cy5.5 alkyne (non-sulfonated)也可用于标记小分子。Cy5.5 alkyne (non-sulfonated)是一种远红外/近红外染料炔，含有乙炔基，用于点击化学标记。Cyanine5.5是Cy5.5®的类似物，Cy5.5®是一种常见的荧光团，被广泛用于各种应用，包括完整的生物体成像。Cy5.5 alkyne (non-sulfonated)在温和铜催化的点击化学条件下可以与叠氮基团结合。Cy5.5 alkyne (non-sulfonated)可溶于有机溶剂，但水与小百分比的DMSO混合物可用于有效的缀合反应。Cy5.5 alkyne (non-sulfonated)也可用于标记小分子。Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CN1C2=CC=C3C=CC=CC3=C2C(C)(C)/C1=C\C=C\C=C\C4=[N+](CCCCCC(NCC#C)=O)C5=CC=C(C=CC=C6)C6=C5C4(C)C.[Cl-] 分子式 C43H46ClN3O 分子量 656.3 溶解度 >65.6 mg/mL in DMSO; insoluble in H2O; >13 mg/mL in EtOH 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while
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Cy5.5
作者：德尔塔 日期：2022-09-26
Cy5.5 (Sulfo-Cyanine5.5) 是用于标记生物分子的近红外荧光染料 (Ex=673 nm, Em=707 nm)，如肽，蛋白质和寡核苷酸。Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) used to label biological molecules, such as peptides, proteins, and oligonucleotides[1].[1]. Zhu S, et al. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J Drug Target. 2015 Apr;23(3):257-65. [2]. Jiang L, et al. pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. Biomaterials. 2013 Oct;34(30):7418-28. [3]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) used to label biological molecules, such as peptides, proteins, and oligonucleotides[1].[1]. Zhu S, et al. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J Drug Target. 2015 Apr;23(3):257-65. [2]. Jiang L, et al. pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. Biomaterials. 2013 Oct;34(30):7418-28. [3]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombo
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CY5-YNE
作者：德尔塔 日期：2022-09-26
CY5-YNE是一种用于标记肽,蛋白质,寡核苷酸的氨基基团的反应染料。CY5-YNE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.CY5-YNE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.Cas No. 1345823-20-2 SDF 别名 N/A 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(NCC#C)=O)=C\C=C\C=C\C2=[N+](CC)C(C=CC(S(=O)([O-])=O)=C3)=C3C2(C)C)(C)C4=C1C=CC(S(=O)(O)=O)=C4 分子式 C36H43N3O7S2 分子量 693.87 溶解度 DMSO : ≥ 43 mg/mL (61.97 mM) 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5-SE (triethylamine salt)
作者：德尔塔 日期：2022-09-26
Cy5-SE is a hydrophilic amine-reactive fluorescent probe.1 It displays excitation/emission maxima of 646/662 nm, respectively. Cy5-SE-conjugated ligands have been used in the characterization of hematopoietic tumor microenvironments.1.Soodgupta, D., Zhou, H., Beaino, W., et al.Ex vivo and in vivo evaluation of overexpressed VLA-4 in multiple myeloma using LLP2A imaging agentsJ. Nucl. Med.57(4)640-645(2016)Cy5-SE is a hydrophilic amine-reactive fluorescent probe.1 It displays excitation/emission maxima of 646/662 nm, respectively. Cy5-SE-conjugated ligands have been used in the characterization of hematopoietic tumor microenvironments.1.Soodgupta, D., Zhou, H., Beaino, W., et al.Ex vivo and in vivo evaluation of overexpressed VLA-4 in multiple myeloma using LLP2A imaging agentsJ. Nucl. Med.57(4)640-645(2016)Cas No. 1497420-70-8 SDF 别名 N/A 化学名 N/A Canonical SMILES O=C(CCCCCN1/C(C(C)(C2=C1C=CC(S(O)(=O)=O)=C2)C)=C/C=C/C=C/C3=[N+](C4=CC=C(C=C4C3(C)C)S([O-])(=O)=O)CC)ON5C(CCC5=O)=O.CCN(CC)CC 分子式 C37H43N3O10S2.C6H15N 分子量 855.1 溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it
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CY5-SE
作者：德尔塔 日期：2022-09-26
Cy5-SE是一种用于标记肽, 蛋白质, 寡核苷酸的氨基基团的反应染料。激发波长 (nm): 649, 发射波长 (nm): 670。Cy5-SE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.Cy5-SE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.Cas No. 146368-14-1 SDF 别名 Cy5 NHS Ester 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(ON2C(CCC2=O)=O)=O)=C\C=C\C=C\C3=[N+](CC)C(C=CC(S(=O)([O-])=O)=C4)=C4C3(C)C)(C)C5=C1C=CC(S(=O)(O)=O)=C5 分子式 C37H43N3O10S2 分子量 753.88 溶解度 DMSO: 25 mg/mL (33.16 mM) 储存条件
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