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Sitagliptin-d4 phosphate，磷酸西他列汀 d4 (磷酸盐「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Sitagliptin-d4 (phosphate) is the deuterium labeled Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1][2].IC50 & Target：DPP-4体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sitagliptin-d4 phosphate 相关抗体:DPP4/CD26 Antibody (YA1274)分子量：509.33Formula：C16H14D4F6N5O5PCAS 号：1432063-88-1非标记 CAS：654671-78-0性状：固体颜色：White to off-white中文名称：磷酸西他列汀 d4 (磷酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Quetiapine-d4 hemifumarate，半富马酸奎硫平 D4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Quetiapine-d4 (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].分子量：445.57Formula：C21H21D4N3O2S.1/2C4H4O4CAS 号：1217310-65-0非标记 CAS：111974-72-2性状：固体颜色：White to off-white中文名称：富马酸喹硫平 d4 (hemifumarate)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Axitinib-13C,d3，AG-013736-13C，d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Axitinib-13C,d3 相关抗体:Phospho-PDGFR beta (Y740) AntibodyVEGF Receptor 2 Antibody (YA014)PDGFR alpha AntibodyVEGF Receptor 1 AntibodyVEGFA AntibodyVEGF Receptor2 Antibody PDGF B Antibody (YA1556)PLGF Antibody (YA1812)PDGFR beta Antibody (YA1925)VEGFD Antibody (YA2385)Phospho-PDGFR beta (Tyr740) Antibody (YA3062)PGF Antibody (YA1434)Neuropilin 1 Antibody (YA1831)VEGFB Antibody (YA2627)分子量：390.48Formula：C2113CH15D3N4OSCAS 号：1261432-00-1非标记 CAS：319460-85-0性状：固体颜色：White to off-white中文名称：阿昔替尼 13C，d3运输条件：Shipping with dry ice.储存方式：-80°C
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α-Terpineol-d3，α-松油醇-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：α-Terpineol-d3 is the deuterium labeled α-Terpineol[1]. α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria[2].α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.α-Terpineol-d3 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：157.27Formula：C10H15D3OCAS 号：203633-12-9非标记 CAS：98-55-5性状：固液混合物颜色：White to off-white中文名称：α-松油醇-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 98.14%参考文献[1]. Russ
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DL-Mevalonolactone-d7，(±-Mevalonolactone-d7; Mevalolactone-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.DL-Mevalonolactone-d7 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：137.18Formula：C6H3D7O3CAS 号：347840-19-1非标记 CAS：674-26-0性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Venetoclax-d8，维奈妥拉-d8; ABT-199-d8; GDC-0199-d8; RG7601-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Venetoclax-d8 相关抗体:Bcl-2 AntibodyBcl2 AntibodyBax Antibody (YA591)Bad AntibodyBak Antibody (YA592)BAX Antibody (YA825)Bcl-XL AntibodyBim AntibodyBNIP3 AntibodyPUMA AntibodyMCL1 AntibodyBak AntibodyBax Antibody (YA826)Bcl2 Antibody (YA824)BNIP3L AntibodyBAG2 Antibody (YA1398)Phospho-PML Protein (Ser518) Antibody (YA2632)Bid AntibodyBAG1 Antibody (YA932)BAG1 Antibody (YA933)Bcl10 Antibody (YA1188)BAP31 Antibody (YA1320)BCL2L1 Antibody (YA1359)BAG3 Antibody (YA2240)Bok Antibody (YA2289)BPR Antibody (YA2393)DYNLL1 Antibody (YA2724)Bcl2 L14 Antibody (YA2740)Bcl2 A1 Antibody (YA2743)Phospho-Bad (Ser112) Antibody (YA3099)分子量：876.49Formula：C45H42D8ClN7O7SCAS 号：1257051-06-1非标记 CAS：1257044-40-8性状：固体颜色：White to yellow中文名称：维奈妥拉-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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SDMA-d6，对称二甲基精氨酸-d6; Symmetric dimethylarginine-d6; NG,NG'-Dimethyl-L-arginine-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：SDMA-d6 is the deuterium labeled SDMA. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.SDMA-d6 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：208.29Formula：C8H12D6N4O2CAS 号：1331888-08-4非标记 CAS：30344-00-4性状：固体颜色：White to light yellow中文名称：对称二甲基精氨酸-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Kynurenic acid-d5，Quinurenic acid-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].IC50 & Target：NMDA Receptor体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Kynurenic acid-d5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 AntibodyPSD95 Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyAIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 Antibody分子量：194.20Formula：C10H2D5NO3CAS 号：350820-13-2非标记 CAS：492-27-3性状：固体颜色：White to off-white中文名称：犬尿喹啉酸 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solven
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4'-Hydroxy diclofenac-d4，4′-羟基双氯芬酸 d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：4'-Hydroxy diclofenac-d4 is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.4'-Hydroxy diclofenac-d4 相关抗体:FMO3 Antibody (YA1992)分子量：316.17Formula：C14H7D4Cl2NO3CAS 号：254762-27-1非标记 CAS：64118-84-9性状：固体颜色：White to light yellow中文名称：4′-羟基双氯芬酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Citric acid-13C6，柠檬酸 13C6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Citric acid-13C6 is the 13C-labeled Citric acid. Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Citric acid-13C6 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyAIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 Antibody分子量：198.08Formula：13C6H8O7CAS 号：287389-42-8非标记 CAS：77-92-9性状：固体颜色：White to light yellow中文名称：柠檬酸 13C6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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S-Adenosyl-L-methionine-d3，S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.S-Adenosyl-L-methionine-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyAIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 Antibody分子量：401.46Formula：C15H19D3N6O5SCAS 号：68684-40-2非标记 CAS：29908-03-0性状：固体颜色：White to light yellow中文名称：S-腺苷-L-蛋氨酸 d3运输条件：Room temperature in continental
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L-Glutamine-d5，L-Glutamic acid 5-amide-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：L-Glutamine-d5 is the deuterium labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.L-Glutamine-d5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyFMRP AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMetabotropic glutamate receptor 5 AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Glutamate receptor 1 AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyAMID/FSP1 Antibody分子量：151.18Formula：C5H5D5N2O3CAS 号：14341-78-7非标记 CAS：56-85-9性状：固体颜色：White to off-white中文名称：L-谷氨酰胺 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, aw
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Quinolinic acid-d3，喹啉酸 d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].IC50 & Target：NMDA Receptor体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Quinolinic acid-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyPSD95 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNMDAR1 AntibodyNMDAR2A AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量：170.14Formula：C7H2D3NO4CAS 号：138946-42-6非标记 CAS：89-00-9性状：固体颜色：White to off-white中文名称：喹啉酸 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 ye
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Sorafenib-d3，Donafenib; Bay 43-9006-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。氘代化合物的潜在优势： (1) 延长半衰期体内。氘代化合物可能能够延长化合物的药代动力学特征，即延长体内半衰期。这可以提高化合物的安全性、功效和耐受性，并增加给药的便利性。 (2) 提高口服生物利用度。氘化化合物可以降低肠壁和肝脏中不需要的代谢 (首过代谢) 的程度，使更大比例的未代谢药物到达其作用靶点。高生物利用度决定了它在低剂量下的活性和更好的耐受性。 (3) 改善代谢特性。氘代化合物可以减少有毒或反应性代谢物的形成并改善药物代谢。 (四) 提高用药安全性。氘代化合物可以减少或消除药物化合物的不良副作用并且是安全的。 (5) 保持疗效。在先前的研究中，预计氘代化合物将保留与氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sorafenib-d3 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyBRAF Antibodyc-Myc AntibodyCyclin E1 AntibodyPhospho-BRAF (Thr401) AntibodyAIF Antibody (YA636)ALIX AntibodyA-RAF AntibodyB-Raf AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygena
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Arachidonic acid-13C4，Immunocytophyt-13C4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Arachidonic acid-13C4 (Immunocytophyt-13C4) is 13C labeled Arachidonic acid. Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function[1][1][2].分子量：308.44Formula：C1613C4H32O2CAS 号：2692624-40-9非标记 CAS：506-32-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (519 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Tateishi N, et al. Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. Lipids Health Dis. 2015 Jan 16;14:3. [Content Brief]
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