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Palbociclib-d8，PD 0332991-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-06-05
生物活性：Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].IC50 & Target[1]：Cdk4/cyclin D39 nM (IC50)Cdk4/cyclin D111 nM (IC50)Cdk6/cyclin D216 nM (IC50)DYRK1A2000 nM (IC50)MAPK8000 nM (IC50)体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Palbociclib-d8 相关抗体:Cyclin E1 Antibody (YA483)CD133 AntibodyCdk2 AntibodyCdk4 AntibodyCdk5 AntibodyCdk6 AntibodyCyclin D3 AntibodyCdk7 AntibodyCDK16 AntibodyCDK5 Antibody (YA796)CDK9 AntibodyCDKN2A/p16INK4a Antibody (YA508)Phospho-CDK1 (Tyr15) AntibodyPhospho-CDK1/2/3 (Thr14) AntibodyPhospho-CDK2 (Tyr15) AntibodyPhospho-Cyclin B1 (Ser126) AntibodyCDKN2A/p16INK4a AntibodyCDKN2C AntibodyPhospho-CDC6 (Ser54) Antibody (YA1017)Cyclin E2 Antibody (YA2594)CDC25C Antibody (YA2624)CDC6 Antibody (YA2626)CDC40 Antibody (YA3168)Cyclin A1/A2 Antibody (YA3336)CRK Antibody (YA790)Cyclin H Antibody (YA788)Cyclin H AntibodyPhospho-CDC6 (Ser106) Antibody (YA1016)CDC7 Antibody (YA1152)Cyclin D3/CCND3 Antibody (YA1201)分子量：455.58Formula：C24H21D8N7O2CAS 号：1628752-83-9非标记 CAS：571190-30-2性状：固体颜色：Light yellow to yellow中文名称：帕布昔利布 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C
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Abemaciclib-d8，LY2835219-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-06-05
生物活性：Abemaciclib-d8 is the deuterium labeled Abemaciclib. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Abemaciclib-d8 相关抗体:Cyclin E1 Antibody (YA483)CD133 AntibodyCdk2 AntibodyCdk4 AntibodyCdk5 AntibodyCdk6 AntibodyCyclin D3 AntibodyCdk7 AntibodyCDK16 AntibodyCDK5 Antibody (YA796)CDK9 AntibodyCDKN2A/p16INK4a Antibody (YA508)Phospho-CDK1 (Tyr15) AntibodyPhospho-CDK1/2/3 (Thr14) AntibodyPhospho-CDK2 (Tyr15) AntibodyPhospho-Cyclin B1 (Ser126) AntibodyCDKN2A/p16INK4a AntibodyCDKN2C AntibodyPhospho-CDC6 (Ser54) Antibody (YA1017)Cyclin E2 Antibody (YA2594)CDC25C Antibody (YA2624)CDC6 Antibody (YA2626)CDC40 Antibody (YA3168)Cyclin A1/A2 Antibody (YA3336)CRK Antibody (YA790)Cyclin H Antibody (YA788)Cyclin H AntibodyPhospho-CDC6 (Ser106) Antibody (YA1016)CDC7 Antibody (YA1152)Cyclin D3/CCND3 Antibody (YA1201)分子量：514.64Formula：C27H24D8F2N8CAS 号：2088650-53-5非标记 CAS：1231929-97-7性状：固体颜色：White to yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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L-Tyrosine-d4，L-酪氨酸 D4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-06-05
生物活性：L-Tyrosine-d4 is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[1].体外研究(In Vitro)：L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM)[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.L-Tyrosine-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：185.21Formula：C9H7D4NO3CAS 号：62595-14-6非标记 CAS：60-18-4性状：固体颜色：White to off-white中文名称：L-酪氨酸-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Aspirin-d3，Acetylsalicylic Acid-d3; ASA-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-06-05
生物活性：Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Aspirin-d3 相关抗体:S100A10 Antibody (YA675)COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：183.18Formula：C9H5D3O4CAS 号：921943-73-9非标记 CAS：50-78-2性状：固体颜色：White to off-white中文名称：阿司匹林 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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BMS-986202「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-06-05
生物活性：BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium[1].IC50 & Target[1]：Tyk2 JH20.19 nM (IC50)Tyk2 JH20.02 nM (Ki)CYP2C1914 μM (IC50)体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。氘代化合物的潜在优势： (1) 延长半衰期体内。氘代化合物可能能够延长化合物的药代动力学特征，即延长体内半衰期。这可以提高化合物的安全性、功效和耐受性，并增加给药的便利性。 (2) 提高口服生物利用度。氘化化合物可以降低肠壁和肝脏中不需要的代谢 (首过代谢) 的程度，使更大比例的未代谢药物到达其作用靶点。高生物利用度决定了它在低剂量下的活性和更好的耐受性。(3) 改善代谢特性。氘代化合物可以减少有毒或反应性代谢物的形成并改善药物代谢。 (四) 提高用药安全性。氘代化合物可以减少或消除药物化合物的不良副作用并且是安全的。(5) 保持疗效。在先前的研究中，预计氘代化合物将保留与氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.BMS-986202 相关抗体:Phospho-JAK2 (Tyr1007/1008) AntibodyCytochrome C AntibodyJAK1 Antibody (YA722)JAK1 AntibodyJAK2 Antibody (YA721)Cytochrome P450 17A1 AntibodyPhospho-JAK2 (Tyr1007+Tyr1008) AntibodyAromatase A
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CAS:65100-45-0|Imipramine-d6，盐酸丙咪嗪-d6
作者：德尔塔生物 日期：2025-06-05
生物活性：Imipramine-d6 is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Imipramine-d6 相关抗体:Serotonin Transporter Antibody (YA1638)HTR7 Antibody (YA2796)HTR2C Antibody (YA3364)分子量：286.44Formula：C19H18D6N2CAS 号：65100-45-0非标记 CAS：113-52-0中文名称：丙咪嗪-d6；丙米嗪-d6；米帕明-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (538 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cel
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CAS:1227097-70-2|Dorzolamide-d5，多佐胺-d5
作者：德尔塔生物 日期：2025-06-05
生物活性：Dorzolamide-d5 is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].IC50 & Target：CA Ⅱ体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：329.47Formula：C10H11D5N2O4S3CAS 号：1227097-70-2非标记 CAS：120279-96-1中文名称：多佐胺-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (533 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60. [Content Brief][3]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8. [Content Brief][4]. Belal M Ali, et al.
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CAS:959119-25-6|Erythromycin-d6，红霉素 d6
作者：德尔塔生物 日期：2025-06-05
生物活性：Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].IC50 & Target：Macrolide体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Erythromycin-d6 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：739.96Formula：C37H61D6NO13CAS 号：959119-25-6非标记 CAS：114-07-8中文名称：红霉素 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the C
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CAS:1182838-09-0|Methyl syringate-d6
作者：德尔塔生物 日期：2025-06-05
生物活性：Methyl syringate-d6 is the deuterium labeled Methyl syringate. Methyl syringate is a selective TRPA1agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis[1][2][3][4].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Methyl syringate-d6 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyPFKFB3 AntibodyDUSP1 AntibodyDUSP3 AntibodyCOX IV Antibody (YA867)MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Intestinal Alkaline Phosphatase Antibody (YA1559)PFKL Antibody (YA1597)TRPM8 Antibody (YA1609)SHP2 Antibody (YA1643)PP1C alpha/beta Antibody (YA1700)PTP1B Antibody (YA1776)PLEKHA1 Antibody (YA2145)PGAM1 Antibody (YA2156)DUSP6 Antibody (YA2280)TRPM7 Antibody (YA2391)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)PRAS40 Antibody (YA3179)PPP4C Antibody (YA6
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CAS:1261170-81-3|Ferulic acid-13C3
作者：德尔塔生物 日期：2025-06-05
生物活性：Ferulic acid-13C3 is the 13C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ferulic acid-13C3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyFGFR2/CD332 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)FGFR1 AntibodyFGFR1 Oncogene Partner AntibodyFGFR2 AntibodyFGFR3 AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin Antibody分子量：197.16Formula：C713C3H10O4CAS 号：1261170-81-3非标记 CAS：1135-24-6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuteri
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CAS:90412-47-8|o-Phenanthroline-d8，1,10-Phenanthroline-d8
作者：德尔塔生物 日期：2025-06-05
生物活性：o-Phenanthroline-d8 is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.o-Phenanthroline-d8 相关抗体:MMP3 AntibodyMMP12 AntibodyTIMP2 AntibodyMMP9 Antibody (YA285)MMP2 AntibodyMMP1 AntibodyMMP9 AntibodyMMP7 AntibodyMMP11 Antibody (YA2682)MMP8 Antibody (YA3030)MMP13 Antibody (YA3143)MMP14 Antibody (YA1590)MMP17 Antibody (YA1728)RYBP Antibody (YA1797)MMP26 Antibody (YA3240)分子量：188.25Formula：C12D8N2CAS 号：90412-47-8非标记 CAS：66-71-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (534 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Guan NanMu, et al. Synergistic inh
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CAS:26473-08-5|1,4-Naphthoquinone-d6
作者：德尔塔生物 日期：2025-06-05
生物活性：1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models[1][2][3][4][5][6].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.1,4-Naphthoquinone-d6 相关抗体:NF-KB p65 AntibodyPhospho-NF-KB p65 (Ser536) AntibodyTNF alpha AntibodyPhospho-NF-κB p65 (Ser529) AntibodyCtip2 AntibodyNF-KB p65 Antibody (YA267)Rb AntibodyPhospho-Rb (Ser807) AntibodyTNF Receptor 2 AntibodyRPA32 Antibody (YA679)CD40 AntibodyCD40L AntibodyCDT1 AntibodyDNA-PK
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CAS:2747915-18-8|Trimebutine-d5 fumarate，曲美布汀-d5
作者：德尔塔生物 日期：2025-06-05
生物活性：Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS)[1][2][3][4][5][6][7].IC50 & Target：μ Opioid Receptor/MORL-type calcium channelIRAK-1ERK1ERK2体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Trimebutine-d5 fumarate 相关抗体:Annexin VI AntibodyERK1/2 AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) AntibodyNF-KB p65 AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)Phospho-NF-KB p65 (Ser536) AntibodyE-Cadherin Antibody (YA470)IRF3 AntibodyFatty Acid Synthase Antibody (YA766)Phospho-AKT1 (Ser473) AntibodyAKT1/2/3 Anti
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CAS:1219798-56-7|Propoxur-d3，残杀威-d3
作者：德尔塔生物 日期：2025-06-05
生物活性：Propoxur-d3 is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3][4].IC50 & Target：MMP-2AChE体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Propoxur-d3 相关抗体:ERK1/2 AntibodyPGK1 AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)ERK2 AntibodyMMP3 AntibodyKeap1 AntibodyMMP12 AntibodyPhospho-Nrf2 (Ser40) Antibody (YA169)Catalase Antibody (YA552)Catalase Antibody (YA811)ERK5 AntibodyTIMP2 AntibodyERK1 AntibodyMMP9 Antibody (YA285)Phospho-Nrf2 (Ser40) Antibody (YA168)MMP2 AntibodyKGF AntibodyMMP1 AntibodyMMP9 AntibodyPhospho-ERK1/2 (Thr202/Thr185) AntibodyPhospho-ERK1/2 (Tyr204/Tyr18
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CAS:39756-37-1|Heneicosane-d44，正二十一烷-d44
作者：德尔塔生物 日期：2025-06-05
生物活性：Heneicosane-d44 is the deuterium labeled Heneicosane (HY-W089845). Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs[1][2][3][4][5].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Heneicosane-d44 相关抗体:SDHA Antibody分子量：340.85Formula：C21D44CAS 号：39756-37-1中文名称：正二十一烷-d44运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (549 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharma
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