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Mosapride-d5，莫沙必利-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Mosapride-d5 is the deuterium labeled Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Mosapride-d5 相关抗体:MTNR1A Antibody分子量：426.92Formula：C21H20D5ClFN3O3CAS 号：1246820-66-5非标记 CAS：112885-41-3中文名称：莫沙必利-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (523 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Tack J, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67. [Content Brief][3]. Curran MP, et al. Mosapride in gastrointestinal disorders. Drugs. 2008;68(7):981-91. [Content Brief][4]. Odaka T, et al. Serotonin 5- HT4 receptor agonist (mosapride citrate). Nihon Rinsho. 2006 Aug;64(8):1491-4. [Content Brief]
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Artemisinin-d3，Qinghaosu-d3; NSC 369397-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].IC50 & Target：Plasmodium体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Artemisinin-d3 相关抗体:Phospho-AKT1 (Ser473) AntibodyAKT1/2/3 Antibody (YA633)Ferritin Heavy Chain AntibodyPhospho-AKT (Thr308) AntibodyPhospho-AKT1(Ser473) AntibodyAKT1 Antibody (YA834)AKT1 Antibody (YA634)Cyclophilin A AntibodyAKT1/AKT2/AKT3 Antibody (YA635)Cyclophilin B Antibody (YA787)AMID/FSP1 AntibodyPeroxiredoxin 1 Antibody (YA692)PRDX3 Antibody (YA909)TRIB3 Antibody (YA2174)Ferritin Light Chain Antibody (YA971)Ferritin Light Chain Antibody (YA972)PDPK1 Antibody (YA1569)AS160 Antibody (YA2170)MPP1 Antibody (YA3077)分子量：285.35Formula：C15H19D3O5CAS 号：176652-07-6非标记 CAS：63968-64-9中文名称：青蒿素 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product unde
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Cefadroxil-d4 hydrate，BL-S 578-d4 hydrate「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Cefadroxil-d4 (hydrate) is the deuterium labeled Cefadroxil. Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.IC50 & Target：β-lactam体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cefadroxil-d4 hydrate 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：385.43Formula：C16H15D4N3O6SCAS 号：1426174-38-0非标记 CAS：66592-87-8中文名称：头孢羟氨苄 d4 (hydrate)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Ph
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Azasetron-d3 hydrochloride，(Rac-SENS-401-d3 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Azasetron-d3 (hydrochloride) is the deuterium labeled Azasetron hydrochloride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：389.29Formula：C17H18D3Cl2N3O3CAS 号：1216505-58-6非标记 CAS：123040-69-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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Proguanil-d4 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Proguanil-d4 (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].IC50 & Target：Plasmodium体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：294.22Formula：C11H13D4Cl2N5CAS 号：1189671-34-8非标记 CAS：637-32-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [Content Brief][3]. Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9. [Content Brief][4]. Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 recepto
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Nabumetone-d3，BRL14777-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Nabumetone-d3 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：231.30Formula：C15H13D3O2CAS 号：1216770-08-9非标记 CAS：42924-53-8中文名称：萘丁美酮 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6. [Content Brief][3]. Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-met
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Lornoxicam-d4，Chlortenoxicam-d4; Ro 13-9297-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Lornoxicam-d4 is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Lornoxicam-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)COX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量：375.84Formula：C13H6D4ClN3O4S2CAS 号：1216527-48-8非标记 CAS：70374-39-9中文名称：氯诺昔康 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium
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Ranolazine-d3，雷诺嗪 d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Ranolazine-d3 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ranolazine-d3 相关抗体:Annexin VI AntibodyxCT Antibody (YA006)Calbindin AntibodyCalreticulin AntibodyxCT Antibody (YA652)Cardiac Troponin I/TNNC1 AntibodyAlpha-ENaC AntibodySCGN Antibody (YA1167)RAMP1 Antibody (YA1818)Annexin V Antibody (YA1829)Striatin 4 Antibody (YA2088)Fibulin 5 Antibody (YA2448)RASGRP1 Antibody (YA2546)Fibulin 1 Antibody (YA2831)EFEMP1 Antibody (YA2883)CRCP Antibody (YA3350)CRMP2 Antibody (YA3370)Annexin VII Antibody (YA1138)Parvalbumin Antibody (YA1249)SLC12A1 Antibody (YA1403)Annexin IV Antibody (YA1921)SERCA2 ATPase Antibody (YA1931)CRMP1 Antibody (YA1941)Stromal Interaction Molecule 1 Antibody (YA2092)SERCA1 ATPase Antibody (YA2157)TrpV5 Antibody (YA2284)NCX1 Antibody (YA2331)Scramblase 1 Antibody (YA2419)CRMP5 Antibody (YA2497)CRMP3 Antibody (
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Carbamazepine-d2，CBZ-d2; NSC 169864-d2「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Carbamazepine-d2 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Carbamazepine-d2 相关抗体:xCT Antibody (YA006)xCT Antibody (YA652)Alpha-ENaC AntibodyCRMP2 Antibody (YA3370)SLC12A1 Antibody (YA1403)CRMP1 Antibody (YA1941)CRMP5 Antibody (YA2497)CRMP3 Antibody (YA2563)CRMP4 Antibody (YA2777)分子量：238.28Formula：C15H10D2N2OCAS 号：1189902-21-3非标记 CAS：298-46-4中文名称：卡马西平 d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (535 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [Content Brief][3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum
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Phenylbutazone-d9，保泰松 d9「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Phenylbutazone-d9 is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Phenylbutazone-d9 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：317.43Formula：C19H11D9N2O2CAS 号：1189479-75-1非标记 CAS：50-33-9中文名称：保泰松 d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (538 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for pero
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Apalutamide-d3，ARN-509-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Apalutamide-d3 is the deuterium labeled Apalutamide[1]. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Apalutamide-d3 相关抗体:Androgen receptor AntibodyPOMC Antibody (YA1619)分子量：480.45Formula：C21H12D3F4N5O2SCAS 号：1638885-61-6非标记 CAS：956104-40-8性状：固体颜色：White to off-white中文名称：阿帕鲁胺-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72(6):1494-503. [Content Brief][3]. Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)301
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Ceritinib-d7，LDK378 d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Ceritinib-d7 is a deuterium labeled Ceritinib. Ceritinib is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor[1].分子量：565.18Formula：C28H29D7ClN5O3SCAS 号：1632484-77-5非标记 CAS：1032900-25-6性状：固体颜色：White to off-white中文名称：色瑞替尼 d7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Cabotegravir-d5，卡博特韦-d5; GSK-1265744-d5; S/GSK1265744-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Cabotegravir-d5 is deuterium labeled Cabotegravir.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cabotegravir-d5 相关抗体:CD4 AntibodyTARBP2 Antibody (YA1433)SAMHD1 Antibody (YA1542)SV40 T Antigen Antibody (YA3256)CLEC12A Antibody (YA1419)Tat SF1 Antibody (YA2886)分子量：410.38Formula：C19H12D5F2N3O5CAS 号：2750534-77-9非标记 CAS：1051375-10-0性状：固体颜色：White to off-white中文名称：卡博特韦-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.31%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Reese MJ, Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12. [Content Brief][3]. Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12. [Content Brief][4]. Bowers GD, Disposition and metabolism of c
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Imatinib-d3 hydrochloride，STI571-d3 hydrochloride; CGP-57148B-d3 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.细胞效力(Cellular Effect)BaF3Cell Line TypeValueDescriptionReferencesBaF3IC50436 nMCompound: 3Inhibition of human BCR-ABL1 autophosphorylation expressed in mouse BA/F3 cells by ELISAInhibition of human BCR-ABL1 autophosphorylation expressed in mouse BA/F3 cells by ELISA[PMID: 23611771]BaF3IC50682 nMCompound: 3Inhibition of human BCR-ABL1 expressed in mouse BA/F3 cells assessed as cell growth inhibition by ATP-depletion assayInhibition of human BCR-ABL1 expressed in mouse BA/F3 cells assessed as cell growth inhibition by ATP-depletion assay[PMID: 23611771]体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Imatinib-d3 hydrochloride 相关抗体:c-Kit Antibody (YA502)Phospho-PDGFR beta (Y740) AntibodyPDGFR alpha AntibodyPDGF B Antibody (YA1556)PDGFR beta
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Tezacaftor-d4，VX-661-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。然而，Ivacaftor (VX-770，HY-13017) 这种 CFTR 增效剂，有助于延长细胞表面 CFTR 蛋白通道的开放时间。Tezacaftor 与 Ivacaftor 结合，显示出对囊性纤维化和 CFTR Phe508del 突变纯合子疾病的有力效果。此外，Elexacaftor (VX-445，HY-111772) 也是一种 CFTR 校正器。 Elexacaftor-Tezacaftor-Ivacaftor 针对至少有一个 Phe508del 突变的囊性纤维化（CF），通常可避免肺移植适应症[3][4]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Tezacaftor-d4 相关抗体:Calumenin Antibody (YA813)Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT05599230CHC MontlegiaCystic FibrosisSeptember 1, 2022NCT02015507Vertex Pharmaceuticals IncorporatedCystic FibrosisJanuary 2014Phase 1NCT01531673Vertex Pharmaceuticals IncorporatedCystic FibrosisFebruary 2012Phase 2 NCT05576324University of Erlangen-Nürnberg Medical SchoolCystic FibrosisDecember 30, 2020NCT03029455Vertex Pharmaceuticals IncorporatedCystic FibrosisNovember 2016Phase 1NCT02070744Vertex Pharmaceuticals IncorporatedCystic FibrosisMarch 2014Phase 2NCT05699148Nottingham University Hospitals NHS TrustCystic FibrosisApril 1, 2022NCT02516410Vertex Pharmaceuticals IncorporatedCystic FibrosisAugust 2015Phase 3NCT02347657Vertex Pharmaceuticals IncorporatedCystic FibrosisJanuary 2015Ph
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