【产品介绍】：

产品名称 LDN-57444 英文名称 LDN-57444 应用 A potent, reversible, active site-directed UCH-L1 inhibitor 规格或纯度 ≥98% (HPLC) 别名 LDN 57444 英文别名 LDN 57444; 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) 运输条件 冰袋运输 生化机理 UCH-L1 Inhibitor is an isatin O-acyl oxime compound reported to act as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 with greater selectivity over UCH-L3. Additionally, UCH-L1 Inhibitor has been shown to increase proliferation of UCH-L1 expressing tumor cell line SH-SY5Y. Potentially useful for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (K i = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.CAS编号 668467-91-2 溶解性 Soluble in DMSO (20 mg/ml). 储存温度 2-8°C储存 MDL号 MFCD09037562 分子量 397.64 分子式 C17H11Cl3N2O3 PubChem CID 24906255