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「同位素标记抑制剂」Baricitinib-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：Baricitinib-d3 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Baricitinib-d3 相关抗体:Phospho-JAK2 (Tyr1007/1008) AntibodyJAK1 Antibody (YA722)JAK1 AntibodyJAK2 Antibody (YA721)Phospho-JAK2 (Tyr1007+Tyr1008) AntibodyJAK2 Antibody (YA330)Phospho-JNK (Thr183) AntibodyJAK3 Antibody (YA2466)分子量：374.44Formula：C16H14D3N7O2SCAS 号：1564242-30-3非标记 CAS：1187594-09-7性状：固体颜色：White to off-white中文名称：巴瑞克替尼 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Fridman JS, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010 May 1;184(9):5298-307. [Content Brief][3]. Jabbari A, et al. Reversal of Alopecia Areata Following Treatmen
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「同位素标记抑制剂」PSI-6206-13C,d3
作者：德尔塔生物 日期：2025-09-18
生物活性：PSI-6206-13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.分子量：264.23Formula：C913CH10D3FN2O5CAS 号：1256490-42-2非标记 CAS：863329-66-2性状：固体颜色：White to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Repaglinide-d5
作者：德尔塔生物 日期：2025-09-18
生物活性：Repaglinide-d5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus[1].体外研究(In Vitro)：Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Repaglinide-d5 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：457.62Formula：C27H31D5N2O4CAS 号：1217709-85-7非标记 CAS：135062-02-1性状：固体颜色：White to off-white中文名称：瑞格列奈 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」(±)-Naproxen-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：(±)-Naproxen-d3 is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID)[1].分子量：233.28Formula：C14H11D3O3CAS 号：958293-79-3非标记 CAS：23981-80-8性状：固体颜色：Off-white to light yellow中文名称：萘普生 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」IDH1 Inhibitor 7-d2
作者：德尔塔生物 日期：2025-09-18
生物活性：IDH1 Inhibitor 7-d2 is the deuterium labeled IDH1 Inhibitor 7 (HY-150238). IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC50 of less than 100 nM[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.IDH1 Inhibitor 7-d2 相关抗体:IDH1 AntibodyAconitase 2 Antibody (YA2151)Aconitase 1 Antibody (YA2850)分子量：461.48Formula：C22H22D2F3N7OCAS 号：2135309-51-0非标记 CAS：2135309-56-5性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Selexipag-d7
作者：德尔塔生物 日期：2025-09-18
生物活性：Selexipag-d7 is the deuterium labeled Selexipag. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor)[1][2].IC50 & Target：IP体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Selexipag-d7 相关抗体:Prostaglandin D Synthase Antibody (YA1739)DP1 Antibody (YA2766)分子量：503.66Formula：C26H25D7N4O4SCAS 号：1265295-21-3非标记 CAS：475086-01-2性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Teneligliptin-d8
作者：德尔塔生物 日期：2025-09-18
生物活性：Teneligliptin-d8 is a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor[1].IC50 & Target：DPP-4Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT02449330National Cerebral and Cardiovascular CenterDiabetes Mellitus, Type 2June 2015Phase 4NCT02924064Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusSeptember 2016Phase 3NCT02567994Handok Inc.Type 2 Diabetes MellitusApril 2015Phase 3 NCT00628212Mitsubishi Tanabe Pharma CorporationType 2 DiabetesJanuary 2008Phase 2NCT03769870Handok Inc.Diabete MellitusJanuary 11, 2019Phase 1NCT05504239Handok Inc.Type 2 DiabetesOctober 2022Phase 3NCT03793023Handok Inc.Type 2 Diabetes MellitusJanuary 2016NCT04431141Handok Inc.Type 2 Diabetes MellitusSeptember 15, 2020Phase 1NCT02512523Handok Inc.Type 2 Diabetes MellitusAugust 2015Phase 4NCT02314637Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusAugust 2009Phase 3NCT02354222Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusJanuary 2015Phase 3NCT02354235Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusJanuary 2015Phase 3NCT01798238Handok Inc.Type 2 Diabetes MellitusNovember 2012Phase 3NCT00971243Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusAugust 2009Phase 2NCT04446026Yonsei UniversityType 2 Diabetes MellitusJuly 8, 2020Phase 4NCT03011177Handok Inc.Type2 Diabetes MellitusJanuary 2017Phase 4NCT01805830Handok Inc.Type 2 DiabetesMay 2012Phase 3NCT00974090Mitsubishi Tanabe Pharma CorporationType 2 Diabetes MellitusSeptember 2009Phase 3NCT02916706M
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「同位素标记抑制剂」Cariprazine-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Cariprazine-d6 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM)[1].IC50 & Target[1]：Dopamine D2 Receptor0.49 nM (Ki)Dopamine D3 Receptor0.085 nM (Ki)5-HT1A Receptor2.6 nM (Ki)分子量：433.45Formula：C21H26D6Cl2N4OCAS 号：1308278-67-2非标记 CAS：839712-12-8性状：固体颜色：White to off-white中文名称：卡利拉嗪 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Pyronaridine-d4 tetraphosphate
作者：德尔塔生物 日期：2025-09-18
生物活性：Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：914.06Formula：C29H40D4ClN5O18P4CAS 号：1186026-25-4非标记 CAS：76748-86-2性状：固体颜色：Light yellow to yellow中文名称：磷酸咯萘啶-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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「同位素标记抑制剂」Clozapine-d8
作者：德尔塔生物 日期：2025-09-18
生物活性：Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Clozapine-d8 相关抗体:ADRB2 AntibodyDRD2 AntibodyMTNR1A AntibodyDopamine Receptor D3 Antibody (YA1742)DOPA Decarboxylase Antibody (YA2428)Dopamine Receptor D1 Antibody (YA3270)Salbutamol Antibody (YA901)Clenbuterol Antibody (YA904)Muscarinic Acetylcholine receptor M3 Antibodyalpha 1a Adrenergic Receptor Antibody (YA2059)Muscarinic Acetylcholine Receptor M2 Antibody (YA2610)Torsin 1A Antibody (YA2935)PITX3 Antibody (YA2974)HMBS Antibody (YA3061)分子量：334.87Formula：C18H11D8ClN4CAS 号：1185053-50-2非标记 CAS：5786-21-0性状：固体颜色：Light yellow to yellow中文名称：氯氮平-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Uridine triphosphate-13C9,15N2 sodium
作者：德尔塔生物 日期：2025-09-18
生物活性：Uridine triphosphate-13C9,15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.Formula：13C9H1515N2O15P3.xNaCAS 号：285978-18-9非标记 CAS：63-39-8性状：固体颜色：White to off-white中文名称：尿苷三磷酸 13C9,15N2 (钠盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料Data Sheet (499 KB)SDS (393 KB)产品使用指南 (1538 KB)
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「同位素标记抑制剂」Terbinafine-d3 hydrochloride
作者：德尔塔生物 日期：2025-09-18
生物活性：Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Terbinafine-d3 hydrochloride 相关抗体:SDHA AntibodyMRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：330.91Formula：C21H23D3ClNCAS 号：1310012-15-7非标记 CAS：78628-80-5性状：固体颜色：White to off-white中文名称：盐酸特比萘芬 d3 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed s
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「同位素标记抑制剂」Ethyl acetoacetate-d5
作者：德尔塔生物 日期：2025-09-18
生物活性：Ethyl acetoacetate-d5 is the deuterium labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ethyl acetoacetate-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：135.17Formula：C6H5D5O3CAS 号：55514-60-8性状：液体颜色：Colorless to light yellow中文名称：乙酰乙酸乙酯-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Deutenzalutamide-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。氘代化合物的潜在优势：（1）延长体内半衰期。氘代化合物或能够延长化合物的药代动力学特征，即延长体内半衰期。由此可提高化合物安全性、有效性和耐受性，并增加给药的便捷性。（2）提高口服生物利用度。氘代化合物或能够减少肠壁和肝脏中不需要的代谢 (首过代谢) 程度，使得更大比例的未代谢药物到达作用的目标位置。生物利用度高决定其在低剂量下具有活性以及更好的耐受性。（3）改善代谢特征。氘代化合物或能够减少有毒或反应性代谢物的形成，改善药物代谢状况。（4）改进药品安全性。氘代化合物或能够减少或消除药物化合物的不良副作用，具有安全性。（5）保留治疗特性。氘代化合物有望保留和此前研究中氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Deutenzalutamide-d3 相关抗体:Androgen receptor AntibodyPOMC Antibody (YA1619)分子量：467.45Formula：C21H13D3F4N4O2SCAS 号：1443331-82-5非标记 CAS：915087-33-1性状：固体颜色：White to off-white中文名称：恩杂鲁胺 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Flufenamic acid-13C6
作者：德尔塔生物 日期：2025-09-18
生物活性：Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Flufenamic acid-13C6 相关抗体:Annexin VI AntibodyAMPK alpha AntibodyPhospho-AMPK alpha 2 (Thr172) AntibodyCOX2 AntibodyAMPK alpha 2 Antibody (YA833)Phospho-AMPK alpha 2(Ser345) AntibodyAMPK alpha 1 AntibodyCalbindin AntibodyCalreticulin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyAMPK alpha 1 Antibody (YA624)Phospho-AMPK alpha 1 (Ser496) Antibody (YA226)Phospho-Hormone sensitive lipase (Ser853) AntibodyATF4 Antibody (YA605)ATP1A1 AntibodyAMPK alpha 2 Antibody (YA623)AMPK beta 1 AntibodyAMPK gamma 1 AntibodyATF4 AntibodyPhospho-AMPK alpha 1 (Ser496) AntibodyCOX IV Antibody (YA867)Cardiac Troponin I/TNNC1 AntibodySCGN Antibody (YA1167)RAMP1 Antibody (YA1818)Annexi
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