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CAS:2702798-58-9|Pramipexole-d7-1 dihydrochloride，盐酸普拉克索-d7-1；盐酸米拉帕-d7-1
作者：德尔塔生物 日期：2025-07-08
生物活性：Pramipexole-d7-1 (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride[1]. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pramipexole-d7-1 dihydrochloride 相关抗体:DRD2 AntibodyDopamine Receptor D3 Antibody (YA1742)DOPA Decarboxylase Antibody (YA2428)Dopamine Receptor D1 Antibody (YA3270)Torsin 1A Antibody (YA2935)PITX3 Antibody (YA2974)HMBS Antibody (YA3061)分子量：254.83Formula：C10H11D7ClN3SCAS 号：2702798-58-9非标记 CAS：104632-25-9中文名称：盐酸普拉克索-d7-1；盐酸米拉帕-d7-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2)
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CAS:1398065-63-8|Loratadine-d5，Loratidine-d5; SCH 29851-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.IC50 & Target：H1 Receptor体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Loratadine-d5 相关抗体:ADGRE1 (F4/80) Antibody (YA002)ADGRE1 (F4/80) Antibody (YA920)分子量：387.91Formula：C22H18D5ClN2O2CAS 号：1398065-63-8非标记 CAS：79794-75-5性状：固体颜色：White to off-white中文名称：氯雷他定 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:2070015-04-0|Cetirizine-d8 dihydrochloride，盐酸西替利嗪 D8
作者：德尔塔生物 日期：2025-07-08
生物活性：Cetirizine-d8 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].IC50 & Target：H1 Receptor分子量：469.86Formula：C21H19D8Cl3N2O3CAS 号：2070015-04-0非标记 CAS：83881-52-1中文名称：盐酸西替利嗪 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (532 KB)产品使用指南 (1538 KB)参考文献[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [Content Brief][3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. [Content Brief]
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CAS:922731-04-2|Esomeprazole-d6 sodium，埃索美拉唑钠-d6; (S-Omeprazole-d6 sodium; (--Omeprazole-d6 sodium
作者：德尔塔生物 日期：2025-07-08
生物活性：Esomeprazole-d6 sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Esomeprazole-d6 sodium 相关抗体:PMCA1 Antibody (YA1676)分子量：374.44Formula：C17H13D6N3NaO3SCAS 号：922731-04-2非标记 CAS：161796-78-7中文名称：埃索美拉唑钠-d6； 艾司奥美拉唑钠-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46. [Content Brief][3]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-In
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CAS:2117730-84-2|GW9662-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：GW9662-d5 is the deuterium labeled GW9662. GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.GW9662-d5 相关抗体:PPAR alpha AntibodyPPAR gamma AntibodyPPAR gamma Antibody (YA122)PGC1 beta Antibody (YA1411)分子量：281.71Formula：C13H4D5ClN2O3CAS 号：2117730-84-2非标记 CAS：22978-25-2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Leesnitzer LM, et al. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry. 2002 May 28;41(21):6640-50. [Content Brief][3]. Seargent JM, et al. GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumor cells and promotes the anticancer effects of the PPARgamma agonist BRL 49653, inde
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CAS:1134163-29-3|Pioglitazone-d4，U 72107-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Pioglitazone-d4 is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].分子量：360.46Formula：C19H16D4N2O3SCAS 号：1134163-29-3非标记 CAS：111025-46-8性状：固体颜色：White to off-white中文名称：吡格列酮 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:934294-22-1|Lansoprazole-d4，AG-1749-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Lansoprazole-d4 is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid[1].IC50 & Target：Proton Pump Inhibitor分子量：373.39Formula：C16H10D4F3N3O2SCAS 号：934294-22-1非标记 CAS：103577-45-3性状：固体颜色：Off-white to light yellow中文名称：兰索拉唑 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:2260670-12-8|Psychosine-d5，Galactosylsphingosine-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Psychosine-d5 相关抗体:Phospho-PKC alpha (T638) AntibodyPhospho-PKC zeta (T560) AntibodyPKC alpha AntibodyPKC beta 1 AntibodyPKC beta 2 AntibodyPKC delta AntibodyPKC epsilon AntibodyPKC gamma AntibodyEzrin Antibody (YA767)PKC eta AntibodySGK1 Antibody (YA1525)PKC theta Antibody (YA3162)Villin AntibodyPhospho-PKC alpha (Ser657) Antibody (YA1023)Phospho-PKC alpha (Thr638) Antibody (YA1024)PRKCQ Antibody (YA1106)AMHR2 Antibody (YA1337)Phospho-PKC (Ser660) Antibody (YA1394)Phospho-PKC delta (Ser299) Antibody (YA2628)Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631)Phospho-PKC zeta (Thr560) Antibody (YA2679)分子量：466.66Formula：C24H42D5NO7CAS 号：2260670-12-8非标记 CAS：2238-90-6性状：固体颜色：White to off-white中文名称：鞘氨醇半乳糖苷-d5；半乳糖基鞘氨醇-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 mo
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CAS:1448350-02-4|Desoxycarbadox-d3
作者：德尔塔生物 日期：2025-07-08
生物活性：Desoxycarbadox-d3 is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：233.24Formula：C11H7D3N4O2CAS 号：1448350-02-4非标记 CAS：55456-55-8性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料纯度： 99.78%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. MacIntosh AI, et al. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J Assoc Off Anal Chem. 1985;68(4):665-671. [Content Brief][3]. Looft T, et al. Carbadox has both temporary and lasting effects on the swine gut microbiota. Front Microbiol. 2014;5:276. Published 2014 Jun 10. [Content Brief][4]. Zhang K, et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and
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CAS:40632-26-6|Cytarabine-d2，阿糖胞苷 d2
作者：德尔塔生物 日期：2025-07-08
生物活性：Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cytarabine-d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 AntibodyRb AntibodyPhospho-Rb (Ser807) Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyRPA32 Antibody (YA679)AIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CDT1 AntibodyCNPase Antibody分子量：245.23Formula：C9H11D2N3O5CAS 号：40632-26-6非标记 CAS：147-94-4性状：固体颜色：White to off-white中文名称：阿糖胞苷 d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1426174-41-5|Ezetimibe phenoxy glucuronide-d4，Ezetimibe glucuronide-d4; Ezetimibe β-D-glucuronide-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].体内研究(In Vivo)After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：589.57Formula：C30H25D4F2NO9CAS 号：1426174-41-5非标记 CAS：190448-57-8性状：固体颜色：White to off-white中文名称：依泽替米贝葡糖苷酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [Content Brief][2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
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CAS:2043026-13-5|Roxadustat-d5，罗沙司他-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Roxadustat-d5 相关抗体:Ferritin Heavy Chain AntibodyHIF1 alpha AntibodyHIF1 beta AntibodyAMID/FSP1 AntibodyPeroxiredoxin 1 Antibody (YA692)PRDX3 Antibody (YA909)HIF 2 alpha AntibodyCA9 Antibody (YA1368)HIF2 alpha Antibody (YA1445)ORP150 Antibody (YA1478)PHD3 Antibody (YA1612)CITED2 Antibody (YA2596)Ferritin Light Chain Antibody (YA971)Ferritin Light Chain Antibody (YA972)ORP1 Antibody (YA1477)HIF1AN Antibody (YA1907)OS9 Antibody (YA1939)PHD2 Antibody (YA2431)HIF Prolyl Hydroxylases Antibody (YA2975)HLF Antibody (YA2990)PHD1 Antibody (YA3325)分子量：357.37Formula：C19H11D5N2O5CAS 号：2043026-13-5非标记 CAS：808118-40-3性状：固体颜色：White to off-white中文名称：罗沙司他-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： ≥98.0%
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CAS:127685-38-5|Cholesterol-5α,6α-epoxide-d7
作者：德尔塔生物 日期：2025-07-08
生物活性：Cholesterol-5α,6α-epoxide-d7 is deuterium labeled Cholesterol-5α,6α-epoxide.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：409.70Formula：C27H39D7O2CAS 号：127685-38-5非标记 CAS：1250-95-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度： 99.3%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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CAS:1093851-63-8|Oseltamivir-d5，奥司他韦-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oseltamivir-d5 相关抗体:Poliovirus Receptor Antibody (YA2556)分子量：317.44Formula：C16H23D5N2O4CAS 号：1093851-63-8非标记 CAS：196618-13-0中文名称：奥司他韦-d5； 奥斯他韦-d5； 奥司他伟-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]
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CAS:1217686-14-0|4-Hydroxyatomoxetine-d3，托莫西汀杂质24-d3
作者：德尔塔生物 日期：2025-07-08
生物活性：4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor[1].分子量：274.37Formula：C17H18D3NO2CAS 号：1217686-14-0非标记 CAS：435293-66-6性状：固体颜色：Light yellow to yellow中文名称：托莫西汀杂质24-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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