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「同位素标记抑制剂」Isobutylparaben-d4
作者：德尔塔生物 日期：2025-06-11
生物活性：Isobutylparaben-d4 is the deuterium labeled Isobutylparaben. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Isobutylparaben-d4 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyPPAR alpha AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyPPAR gamma AntibodyAIF Antibody (YA636)ALIX AntibodyCatalase Antibody (YA552)Catalase Antibody (YA811)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)分子量：198.25Formula：C11H10D4O3CAS 号：1219805-33-0中文名称：4-羟基苯甲酸异丁酯-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (52
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「同位素标记抑制剂」Bisdemethoxycurcumin-d8
作者：德尔塔生物 日期：2025-06-11
生物活性：Bisdemethoxycurcumin-d8 (Curcumin III-d8) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases[1][2][3][4][5].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Bisdemethoxycurcumin-d8 相关抗体:Ferritin Heavy Chain AntibodyCtip2 AntibodyRb AntibodyPhospho-Rb (Ser807) AntibodyRPA32 Antibody (YA679)CDT1 AntibodyDNA-PKcs/PRKDC AntibodyHes1 AntibodyJunB AntibodyLIN28A AntibodyLin28B AntibodyMCM2 AntibodyNanog AntibodyNucleolin AntibodyPCNA AntibodyPDX1 AntibodyRbBP5 AntibodyS100A4 AntibodySP1 AntibodyBRCA1 Antibody (YA819)Argonaute 2 AntibodyBRCA1 AntibodyElongation Factor 1A1 AntibodyAMID/FSP1 AntibodyKAP1 AntibodyMCM2 Antibody (YA705)MLH1 Antibody (YA703)P Glycoprotein AntibodyPeroxiredoxin 1 Antibody (YA692)RNA Polymerase II Subunit B1 Antibody分子量：316.38Formula：C19H8D8O4CAS 号：2470233-08-8非标记 CAS：33171-05-0性状：固体颜色：Yellow to orange中文名称：双去甲氧基姜黄素 d8运输条件：Room
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「同位素标记抑制剂」Radotinib-d6
作者：德尔塔生物 日期：2025-06-11
生物活性：Radotinib-d6 is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Radotinib-d6 相关抗体:FOXP3 Antibody (YA858)ERK1/2 AntibodyPhospho-JAK2 (Tyr1007/1008) AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyPhospho-STAT3 (Tyr705) Antibody (YA146)STAT3 Antibody (YA056)Phospho-STAT1 (Ser727) Antibody (YA148) c-Myc AntibodyCyclin E1 AntibodyJAK1 Antibody (YA722)Phospho-STAT1 (Tyr701) AntibodyPhospho-STAT3 (Tyr705) AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase
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「同位素标记抑制剂」3,4,5-Trimethoxybenzaldehyde-d3
作者：德尔塔生物 日期：2025-06-11
生物活性：3,4,5-Trimethoxybenzaldehyde-d3 is the deuterium labeled 3,4,5-Trimethoxybenzaldehyde (HY-W009886). 3,4,5-Trimethoxybenzaldehyde is a derivative of benzaldehyde. 3,4,5-Trimethoxybenzaldehyde has antimicrobial activity. 3,4,5-Trimethoxybenzaldehyde is also an important intermediate for the synthesis of various drugs, such as Trimethoprim (HY-B0510)[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.3,4,5-Trimethoxybenzaldehyde-d3 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：199.22Formula：C10H9D3O4CAS 号：1219805-17-0非标记 CAS：86-81-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文
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「同位素标记抑制剂」Ornidazole-d5
作者：德尔塔生物 日期：2025-06-11
生物活性：Ornidazole-d5 is deuterium labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ornidazole-d5 相关抗体:MRP2 AntibodyShh AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Ihh Antibody (YA3011)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：224.66Formula：C7H5D5ClN3O3CAS 号：2747915-64-4非标记 CAS：16773-42-5中文名称：奥硝唑-d5；奥尼达唑-d5；氯丙硝唑-d5；氯甲硝咪唑-d5；硝氯丙唑-d5；氯醇硝唑-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditi
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CAS:1185053-50-2|Clozapine-d8，HF 1854-d8
作者：德尔塔生物 日期：2025-06-10
生物活性：Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Clozapine-d8 相关抗体:ADRB2 AntibodyDRD2 AntibodyMTNR1A AntibodyDopamine Receptor D3 Antibody (YA1742)DOPA Decarboxylase Antibody (YA2428)Dopamine Receptor D1 Antibody (YA3270)Salbutamol Antibody (YA901)Clenbuterol Antibody (YA904)Muscarinic Acetylcholine receptor M3 Antibodyalpha 1a Adrenergic Receptor Antibody (YA2059)Muscarinic Acetylcholine Receptor M2 Antibody (YA2610)Torsin 1A Antibody (YA2935)PITX3 Antibody (YA2974)HMBS Antibody (YA3061)分子量：334.87Formula：C18H11D8ClN4CAS 号：1185053-50-2非标记 CAS：5786-21-0性状：固体颜色：Light yellow to yellow中文名称：氯氮平-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1189986-59-1|Haloperidol-d4，氟哌啶醇D4
作者：德尔塔生物 日期：2025-06-10
生物活性：Haloperidol-d4 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.IC50 & Target：D2 Receptor分子量：379.89Formula：C21H19D4ClFNO2CAS 号：1189986-59-1非标记 CAS：52-86-8性状：固体颜色：White to off-white中文名称：氟哌啶醇 d4 杂质8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (493 KB)产品使用指南 (1538 KB)
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CAS:2704587-24-4|Tyk2-IN-8
作者：德尔塔生物 日期：2025-06-10
生物活性：Tyk2-IN-8 is a selective Tyk-2 inhibitor with an IC50 of 5.7 nM for TYK2-JH2. Tyk2-IN-8 inhibits JAK1-JH1 with IC50 of 3.0 nM. Tyk2-IN-8 can be used for the research of autoimmune disease[1].分子量：425.46Formula：C20H19D3N8O3CAS 号：2704587-24-4性状：固体颜色：Off-white to gray运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:87377-08-0|Indomethacin-d4，吲哚美辛-D4; Indometacin-d4
作者：德尔塔生物 日期：2025-06-10
生物活性：Indomethacin-d4 is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].IC50 & Target[1]：Human COX-118 nM (IC50, in CHO cells)Human COX-226 nM (IC50, in CHO cells)分子量：361.81Formula：C19H12D4ClNO4CAS 号：87377-08-0非标记 CAS：53-86-1性状：固体颜色：White to light yellow中文名称：吲哚美辛 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.78%参考文献[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief][2]. Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593. [Content Brief]
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CAS:1246819-50-0|Febuxostat-d9，非布索坦-D9
作者：德尔塔生物 日期：2025-06-10
生物活性：Febuxostat-d9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.分子量：325.43Formula：C16H7D9N2O3SCAS 号：1246819-50-0非标记 CAS：144060-53-7性状：固体颜色：White to off-white中文名称：非布司他 d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1794789-93-7|Vilazodone-d8，盐酸维拉佐酮 d8
作者：德尔塔生物 日期：2025-06-10
生物活性：Vilazodone-d8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.分子量：449.57Formula：C26H19D8N5O2CAS 号：1794789-93-7非标记 CAS：163521-08-2性状：固体颜色：White to off-white中文名称：盐酸维拉佐酮 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1309935-98-5|6-Sulfatoxy Melatonin-d4
作者：德尔塔生物 日期：2025-06-10
生物活性：6-Sulfatoxy Melatonin-d4 is deuterium labeled Adenophostin A.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：332.37Formula：C13H12D4N2O6SCAS 号：1309935-98-5非标记 CAS：149091-92-9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (523 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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CAS:1258428-05-5|Macitentan-d4，ACT-064992-d4
作者：德尔塔生物 日期：2025-06-10
生物活性：Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].IC50 & Target：ETAETB分子量：592.30Formula：C19H16D4Br2N6O4SCAS 号：1258428-05-5非标记 CAS：441798-33-0性状：固体颜色：Off-white to light yellow中文名称：马西替坦 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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CAS:2182068-00-2|Bexarotene-d4，LGD1069 d4
作者：德尔塔生物 日期：2025-06-10
生物活性：Bexarotene-d4 is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[1][2][3][4][5].分子量：352.50Formula：C24H24D4O2CAS 号：2182068-00-2非标记 CAS：153559-49-0性状：固体颜色：White to off-white中文名称：贝沙罗汀 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:2140306-00-7|Prucalopride-13C,d3，普芦卡必利-13C,d3
作者：德尔塔生物 日期：2025-06-10
生物活性：Prucalopride-13C,d3 is the 13C- and deuterium labeled Prucalopride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[24].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Prucalopride-13C,d3 相关抗体:MTNR1A Antibody分子量：371.88Formula：C1713CH23D3ClN3O3CAS 号：2140306-00-7非标记 CAS：179474-81-8性状：固体颜色：White to off-white中文名称：普芦卡必利-13C,d3；普卢卡必利-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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