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「同位素标记抑制剂」CAS:2182068-00-2|Bexarotene-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Bexarotene-d4 is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[1][2][3][4][5].分子量：352.50Formula：C24H24D4O2CAS 号：2182068-00-2非标记 CAS：153559-49-0性状：固体颜色：White to off-white中文名称：贝沙罗汀 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2140306-00-7|Prucalopride-13C,d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Prucalopride-13C,d3 is the 13C- and deuterium labeled Prucalopride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[24].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Prucalopride-13C,d3 相关抗体:MTNR1A Antibody分子量：371.88Formula：C1713CH23D3ClN3O3CAS 号：2140306-00-7非标记 CAS：179474-81-8性状：固体颜色：White to off-white中文名称：普芦卡必利-13C,d3；普卢卡必利-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1134163-29-3|Pioglitazone-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Pioglitazone-d4 is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].分子量：360.46Formula：C19H16D4N2O3SCAS 号：1134163-29-3非标记 CAS：111025-46-8性状：固体颜色：White to off-white中文名称：吡格列酮 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:934294-22-1|Lansoprazole-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Lansoprazole-d4 is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid[1].IC50 & Target：Proton Pump Inhibitor分子量：373.39Formula：C16H10D4F3N3O2SCAS 号：934294-22-1非标记 CAS：103577-45-3性状：固体颜色：Off-white to light yellow中文名称：兰索拉唑 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2260670-12-8|Psychosine-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Psychosine-d5 相关抗体:Phospho-PKC alpha (T638) AntibodyPhospho-PKC zeta (T560) AntibodyPKC alpha AntibodyPKC beta 1 AntibodyPKC beta 2 AntibodyPKC delta AntibodyPKC epsilon AntibodyPKC gamma AntibodyEzrin Antibody (YA767)PKC eta AntibodySGK1 Antibody (YA1525)PKC theta Antibody (YA3162)Villin AntibodyPhospho-PKC alpha (Ser657) Antibody (YA1023)Phospho-PKC alpha (Thr638) Antibody (YA1024)PRKCQ Antibody (YA1106)AMHR2 Antibody (YA1337)Phospho-PKC (Ser660) Antibody (YA1394)Phospho-PKC delta (Ser299) Antibody (YA2628)Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631)Phospho-PKC zeta (Thr560) Antibody (YA2679)分子量：466.66Formula：C24H42D5NO7CAS 号：2260670-12-8非标记 CAS：2238-90-6性状：固体颜色：White to off-white中文名称：鞘氨醇半乳糖苷-d5；半乳糖基鞘氨醇-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 mo
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「同位素标记抑制剂」CAS:1448350-02-4|Desoxycarbadox-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Desoxycarbadox-d3 is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：233.24Formula：C11H7D3N4O2CAS 号：1448350-02-4非标记 CAS：55456-55-8性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料纯度： 99.78%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. MacIntosh AI, et al. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J Assoc Off Anal Chem. 1985;68(4):665-671. [Content Brief][3]. Looft T, et al. Carbadox has both temporary and lasting effects on the swine gut microbiota. Front Microbiol. 2014;5:276. Published 2014 Jun 10. [Content Brief][4]. Zhang K, et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and
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「同位素标记抑制剂」CAS:40632-26-6|Cytarabine-d2
作者：德尔塔生物 日期：2025-06-13
生物活性：Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cytarabine-d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 AntibodyRb AntibodyPhospho-Rb (Ser807) Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyRPA32 Antibody (YA679)AIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CDT1 AntibodyCNPase Antibody分子量：245.23Formula：C9H11D2N3O5CAS 号：40632-26-6非标记 CAS：147-94-4性状：固体颜色：White to off-white中文名称：阿糖胞苷 d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1426174-41-5|Ezetimibe phenoxy glucuronide-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].体内研究(In Vivo)After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：589.57Formula：C30H25D4F2NO9CAS 号：1426174-41-5非标记 CAS：190448-57-8性状：固体颜色：White to off-white中文名称：依泽替米贝葡糖苷酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [Content Brief][2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
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「同位素标记抑制剂」CAS:2043026-13-5|Roxadustat-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Roxadustat-d5 相关抗体:Ferritin Heavy Chain AntibodyHIF1 alpha AntibodyHIF1 beta AntibodyAMID/FSP1 AntibodyPeroxiredoxin 1 Antibody (YA692)PRDX3 Antibody (YA909)HIF 2 alpha AntibodyCA9 Antibody (YA1368)HIF2 alpha Antibody (YA1445)ORP150 Antibody (YA1478)PHD3 Antibody (YA1612)CITED2 Antibody (YA2596)Ferritin Light Chain Antibody (YA971)Ferritin Light Chain Antibody (YA972)ORP1 Antibody (YA1477)HIF1AN Antibody (YA1907)OS9 Antibody (YA1939)PHD2 Antibody (YA2431)HIF Prolyl Hydroxylases Antibody (YA2975)HLF Antibody (YA2990)PHD1 Antibody (YA3325)分子量：357.37Formula：C19H11D5N2O5CAS 号：2043026-13-5非标记 CAS：808118-40-3性状：固体颜色：White to off-white中文名称：罗沙司他-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： ≥98.0%
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「同位素标记抑制剂」CAS:127685-38-5|Cholesterol-5α,6α-epoxide-d7
作者：德尔塔生物 日期：2025-06-13
生物活性：Cholesterol-5α,6α-epoxide-d7 is deuterium labeled Cholesterol-5α,6α-epoxide.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：409.70Formula：C27H39D7O2CAS 号：127685-38-5非标记 CAS：1250-95-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度： 99.3%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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「同位素标记抑制剂」CAS:1093851-63-8|Oseltamivir-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oseltamivir-d5 相关抗体:Poliovirus Receptor Antibody (YA2556)分子量：317.44Formula：C16H23D5N2O4CAS 号：1093851-63-8非标记 CAS：196618-13-0中文名称：奥司他韦-d5； 奥斯他韦-d5； 奥司他伟-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]
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「同位素标记抑制剂」CAS:1217686-14-0|4-Hydroxyatomoxetine-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor[1].分子量：274.37Formula：C17H18D3NO2CAS 号：1217686-14-0非标记 CAS：435293-66-6性状：固体颜色：Light yellow to yellow中文名称：托莫西汀杂质24-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1216551-07-3|3-Methyl Hippuric acid-d7
作者：德尔塔生物 日期：2025-06-13
生物活性：3-Methyl Hippuric acid-d7 is the deuterium labeled 3-Methyl Hippuric acid[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：200.24Formula：C10H4D7NO3CAS 号：1216551-07-3非标记 CAS：27115-49-7性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:1353940-55-2|Brombuterol-d9
作者：德尔塔生物 日期：2025-06-13
生物活性：Brombuterol-d9 is a deuterium labeled Brombuterol. Brombuterol is a β-adrenergic receptor agonist[1].IC50 & Target：β adrenergic receptor分子量：375.15Formula：C12H9D9Br2N2OCAS 号：1353940-55-2性状：固体颜色：White to off-white中文名称：溴布特罗 d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%参考文献[1]. E Sangiorgi, et al. Application of a Sequential Analytical Procedure for the Detection of the Beta-Agonist Brombuterol in Bovine Urine Samples. J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):468-78. [Content Brief]
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「同位素标记抑制剂」CAS:2699607-19-5|(±)11(12)-EET-d11
作者：德尔塔生物 日期：2025-06-13
生物活性：(±)11(12)-EET-d11 is the deuterium labeled (±)11(12)-EET. (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(±)11(12)-EET-d11 相关抗体:NLRP3 AntibodyNLRP3 AntibodyASC Antibody分子量：331.53Formula：C20H21D11O3CAS 号：2699607-19-5非标记 CAS：87173-81-7性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： 98.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921. [Content Brief][3]. Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922. [Content Brief][4]. Oliw EH, et al. Oxygenation
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