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「同位素标记抑制剂」CAS:1356837-87-0|Penicillin V-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Penicillin V-d5 (Phenoxymethylpenicillin-d5) is the deuterium labeled Penicillin V. Penicillin V (Phenoxymethylpenicillin) is an orally active antibiotic. Penicillin V inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Penicillin V-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：355.42Formula：C16H13D5N2O5SCAS 号：1356837-87-0非标记 CAS：87-08-1性状：固体颜色：White to off-white中文名称：青霉素 V-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.45%参考文献[1]. Russak EM, et al. Impa
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「同位素标记抑制剂」CAS:1190021-64-7|Naratriptan-d3 hydrochloride
作者：德尔塔生物 日期：2025-06-13
生物活性：Naratriptan-d3 (GR-85548A-d3) is the deuterium labeled Naratriptan hydrochloride (HY-B0197A). Naratriptan hydrochloride is a selective 5-HT1B/1D receptor agonist. Naratriptan hydrochloride is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan hydrochloride also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan hydrochloride is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms[1][2][3][4][5].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Naratriptan-d3 hydrochloride 相关抗体:MTNR1A Antibody分子量：374.94Formula：C17H23D3ClN3O2SCAS 号：1190021-64-7非标记 CAS：143388-64-1中文名称：盐酸那拉曲坦 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (547 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Rhoden E, et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination wit
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「同位素标记抑制剂」CAS:1173021-72-1|Azaperone-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Azaperone-d4 is the deuterium labeled Azaperone. Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Azaperone-d4 相关抗体:DRD2 AntibodyDopamine Receptor D3 Antibody (YA1742)DOPA Decarboxylase Antibody (YA2428)Dopamine Receptor D1 Antibody (YA3270)Torsin 1A Antibody (YA2935)PITX3 Antibody (YA2974)HMBS Antibody (YA3061)分子量：331.42Formula：C19H18D4FN3OCAS 号：1173021-72-1非标记 CAS：1649-18-9性状：固体颜色：White to off-white中文名称：阿扎哌隆 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 95.83%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:1217651-73-4|Colchicine-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Colchicine-d6 相关抗体:ERK1/2 Antibodyalpha Tubulin AntibodyLC3A/B AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP AntibodyNLRP3 Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyBeta Tubulin Antibodyc-Myc AntibodyCyclin E1 AntibodyNLRP3 Antibodybeta Tubulin Antibody (YA839)AIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)Doublecortin Antibody分子量：405.47Formula：C22H19D6NO6CAS 号：1217651-73-4非标记 CAS：64-86-8性状：固体颜色：White to off-white中文名称：秋水仙素 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，
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「同位素标记抑制剂」CAS:1416575-78-4|Pomalidomide-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors
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「同位素标记抑制剂」CAS:2403760-70-1|Dosimertinib-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Dosimertinib-d3-d3 is a potent and orally active EGFR inhibitor. Dosimertinib-d3-d3 decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d3-d3 shows antiproliferative and anti-tumor activity. Dosimertinib-d3-d3 has the potential for the research of non-small-cell lung cancer (NSCLC)[1].细胞效力(Cellular Effect)A-431BaF3NCI-H1975Cell Line TypeValueDescriptionReferencesA-431IC50243.9 nMCompound: 2hAntiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assayAntiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay[PMID: 33459024]BaF3IC5018 nMCompound: 2hAntiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assayAntiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assay[PMID: 33459024]BaF3IC503.5 nMCompound: 2hAntiproliferative activity against mouse BaF3 cells harboring EGFR del19/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assayAntiproliferative activity against mouse BaF3 cells harboring EGFR del19/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assay[PMID: 33459024]NCI-H1975IC5028.4 nMCompound: 2hAntiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assayAntiproliferative activity against human NCI-H1975
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「同位素标记抑制剂」CAS:52089-65-3|Adipic acid-d8
作者：德尔塔生物 日期：2025-06-13
生物活性：Adipic acid-d8 (Hexanedioic acid-d8) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Adipic acid-d8 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：154.19Formula：C6H2D8O4CAS 号：52089-65-3非标记 CAS：124-04-9性状：固体颜色：White to off-white中文名称：己二酸-d8；肥酸-d8运输条件：Room temperature in contin
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「同位素标记抑制剂」CAS:204244-84-8|1-Hexanol-d13
作者：德尔塔生物 日期：2025-06-13
生物活性：1-Hexanol-d13 is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.1-Hexanol-d13 相关抗体:Parkin AntibodyMCU AntibodyMitofusin 2 AntibodyLIAS AntibodyNDUFS8 Antibody (YA1352)TOMM20 Antibody (YA1380)NUDT9 Antibody (YA1453)CPS1 Antibody (YA1661)Complex III Subunit 5 Antibody (YA1865)NDUFB8 Antibody (YA1947)MFF Antibody (YA2012)NDUFS4 Antibody (YA2072)MT ND1 Antibody (YA2089)Mitochondrial Fission 1 Protein Antibody (YA2098)Cyclophilin 40 Antibody (YA2099)TIMM44 Antibody (YA2207)NDUFS1 Antibody (YA2535)CLPX Antibody (YA2814)MTCO2 Antibody (YA3254)Mitochondrial Ferritin Antibody (YA3353)mtTFA Antibody (YA3360)Mitofusin 1 AntibodyOrnithine Carbamoyltransferase/OTC Antibody (YA1230)NDUFB10 Antibody (YA1330)NDUFB11 Antibody (YA1331)NDUFB2 Antibody (YA1335)NDUFB4 Antibody (YA1338)NDUFB9 Antibody (YA1340)NDUFC2 Antibody (YA1343)NDUFS3 Antibody (YA1346)分子量：115.25Formula：C6HD13OCAS 号：204244-84-8中文名称：正己醇-d13运输条件：Room temperature in continental US;
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「同位素标记抑制剂」CAS:2159-18-4|1-Hexanol-d11
作者：德尔塔生物 日期：2025-06-13
生物活性：1-Hexanol-d11 is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.1-Hexanol-d11 相关抗体:Parkin AntibodyMCU AntibodyMitofusin 2 AntibodyLIAS AntibodyNDUFS8 Antibody (YA1352)TOMM20 Antibody (YA1380)NUDT9 Antibody (YA1453)CPS1 Antibody (YA1661)Complex III Subunit 5 Antibody (YA1865)NDUFB8 Antibody (YA1947)MFF Antibody (YA2012)NDUFS4 Antibody (YA2072)MT ND1 Antibody (YA2089)Mitochondrial Fission 1 Protein Antibody (YA2098)Cyclophilin 40 Antibody (YA2099)TIMM44 Antibody (YA2207)NDUFS1 Antibody (YA2535)CLPX Antibody (YA2814)MTCO2 Antibody (YA3254)Mitochondrial Ferritin Antibody (YA3353)mtTFA Antibody (YA3360)Mitofusin 1 AntibodyOrnithine Carbamoyltransferase/OTC Antibody (YA1230)NDUFB10 Antibody (YA1330)NDUFB11 Antibody (YA1331)NDUFB2 Antibody (YA1335)NDUFB4 Antibody (YA1338)NDUFB9 Antibody (YA1340)NDUFC2 Antibody (YA1343)NDUFS3 Antibody (YA1346)分子量：113.24Formula：C6H3D11OCAS 号：2159-18-4性状：液体颜色：Colorless to light yellow中文名称：正己醇-d11运输条
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「同位素标记抑制剂」CAS:2704587-24-4|Tyk2-IN-8
作者：德尔塔生物 日期：2025-06-13
生物活性：Tyk2-IN-8 is a selective Tyk-2 inhibitor with an IC50 of 5.7 nM for TYK2-JH2. Tyk2-IN-8 inhibits JAK1-JH1 with IC50 of 3.0 nM. Tyk2-IN-8 can be used for the research of autoimmune disease[1].分子量：425.46Formula：C20H19D3N8O3CAS 号：2704587-24-4性状：固体颜色：Off-white to gray运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:87377-08-0|Indomethacin-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Indomethacin-d4 is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].IC50 & Target[1]：Human COX-118 nM (IC50, in CHO cells)Human COX-226 nM (IC50, in CHO cells)分子量：361.81Formula：C19H12D4ClNO4CAS 号：87377-08-0非标记 CAS：53-86-1性状：固体颜色：White to light yellow中文名称：吲哚美辛 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.78%参考文献[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief][2]. Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593. [Content Brief]
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「同位素标记抑制剂」CAS:1246819-50-0|Febuxostat-d9
作者：德尔塔生物 日期：2025-06-13
生物活性：Febuxostat-d9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.分子量：325.43Formula：C16H7D9N2O3SCAS 号：1246819-50-0非标记 CAS：144060-53-7性状：固体颜色：White to off-white中文名称：非布司他 d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1794789-93-7|Vilazodone-d8
作者：德尔塔生物 日期：2025-06-13
生物活性：Vilazodone-d8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.分子量：449.57Formula：C26H19D8N5O2CAS 号：1794789-93-7非标记 CAS：163521-08-2性状：固体颜色：White to off-white中文名称：盐酸维拉佐酮 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1309935-98-5|6-Sulfatoxy Melatonin-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：6-Sulfatoxy Melatonin-d4 is deuterium labeled Adenophostin A.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：332.37Formula：C13H12D4N2O6SCAS 号：1309935-98-5非标记 CAS：149091-92-9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (523 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:1258428-05-5|Macitentan-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].IC50 & Target：ETAETB分子量：592.30Formula：C19H16D4Br2N6O4SCAS 号：1258428-05-5非标记 CAS：441798-33-0性状：固体颜色：Off-white to light yellow中文名称：马西替坦 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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