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CAS:917879-39-1|MK-2461
作者：德尔塔 日期：2022-03-15
产品名称 MK-2461 英文名称 MK-2461 规格或纯度 ≥99%CAS编号 917879-39-1 敏感性 比旋光度 折光率 凝固点 沸点 溶解性 DMSO
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CAS:857876-30-3|Motesanib Diphosphate (AMG-706)
作者：德尔塔 日期：2022-03-15
产品名称 Motesanib Diphosphate (AMG-706) 英文名称 Motesanib Diphosphate (AMG-706) 应用 An ATP-competitive inhibitor. 规格或纯度 ≥98% 别名 二磷酸莫替沙尼;AMG 706 生化机理 Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM and 59 nM, respectively.CAS编号 857876-30-3
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CAS:656247-17-5|Nintedanib (BIBF 1120)
作者：德尔塔 日期：2022-03-15
产品名称 Nintedanib (BIBF 1120) 英文名称 Nintedanib (BIBF 1120) 应用 BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors. 规格或纯度 ≥98% 别名 BIBF 1120;尼达尼布 英文别名 Vargatef; Intedanib;Nintedanib; BIBF1120; BIBF-1120;(Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}phenylamino)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido 运输条件 超低温冰袋运输
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CAS:698387-09-6|Neratinib (HKI-272)
作者：德尔塔 日期：2022-03-15
产品名称 Neratinib (HKI-272) 英文名称 Neratinib (HKI-272) 应用 A potent and selective inhibitor of EGFR and HER2 规格或纯度 ≥99% 别名 来那替尼 生化机理 Neratinib is a potent and selective inhibitor of EGFR and Neu(HER2) (IC50 = 92 nM and 59 nM, respectively) by preventing phosphorylation of these proteins by their respective kinases. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib is an inhibitor of c-Src and Flk-1.CAS编号 698387-09-6 敏感性
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CAS:343787-29-1|CP-673451
作者：德尔塔 日期：2022-03-15
产品名称 CP-673451 英文名称 CP-673451 规格或纯度 ≥98% 别名 CP 673451;CP673451 英文别名 CP 673451; CP673451;1-[2-[5-(2-methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine 运输条件 超低温冰袋运输 生化机理 有效和选择性的PDGFR抑制剂（PDGFR-α和β的IC50值分别为1和10 nM）。在一系列相关激酶中对PDGFR激酶具有选择性。胶质母细胞瘤异种移植物中的PDGFR-β磷酸化异常和PDGF诱导的小鼠血管生成。CAS编号 343787-29-1
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CAS:1374640-70-6|CO-1686(AVL-301)
作者：德尔塔 日期：2022-03-15
产品名称 CO-1686(AVL-301) 英文名称 CO-1686 (AVL-301) 规格或纯度 ≥99% 生化机理 Description:IC50 Value: 21.5±1.7 nM (EGFRL858R/T790M); 303.3 ± 26.7 nM (EGFRWT) [1]CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M while exhibiting minimal activity towards the wild-type (WT) receptor.in vitro: CO-1686 is a potent inhibitor of EGFR L858R/T790M kinase (kinact/Ki = (2.41 ± 0.30) x 105 M-1s-1) and is approximately 22-fold selective over WT EGFR (kinactt/Ki = (1.12 ± 0.14) x 104 M-1s-1). CO-1686 potently inhibited proliferation in the mutant-EGFR NSCLC cellswith GI50 values ranging from 7 - 32 nM. In comparison, the GI50 value for A431 cells, an epidermoid cell line that is driven by amplified WT EGFR(19), was 547 nM. Two cell linesexpressing WT EGFR in the presence of an N- or KRAS mutation (NCI-H1299 and NCI-H358,respectively) were inhibited by CO-1686 at a concentration of 4275 and 1806 nM, respectively [1].CAS编号 1374640-70-6
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CAS:24502-79-2|(β,β-二甲基丙烯酰基)紫草素
作者：德尔塔 日期：2022-03-15
产品名称 (β,β-二甲基丙烯酰基)紫草素 英文名称 (β,β-Dimethylacryl)shikonin 规格或纯度 >90.0%(HPLC) 别名 BATA,BATA-二甲基丙烯酰紫草素 英文别名 5,8-Dihydroxy-2-[1-(β,β-dimethylacryloyloxy)-4-methyl-3-pentenyl]-1,4-naphthalenedioneCAS编号 24502-79-2 敏感性 熔点 103-105℃
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CAS:845272-21-1|Varlitinib
作者：德尔塔 日期：2022-03-15
产品名称 Varlitinib 英文名称 Varlitinib 规格或纯度 ≥96%CAS编号 845272-21-1 敏感性 比旋光度 折光率 凝固点 沸点 溶解性
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CAS:443913-73-3|Vandetanib(ZD6474)
作者：德尔塔 日期：2022-03-15
产品名称 Vandetanib(ZD6474) 英文名称 Vandetanib (ZD6474) 应用 An antagonist of VEGFR (Flk and Flk) and EGFR families. 规格或纯度 ≥99% 别名 凡德他尼 英文别名 ZD6474;N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 运输条件 超低温冰袋运输 生化机理 口服有效的VEGFR2酪氨酸激酶\ xa0抑制剂\ xa0（KDR IC 50 = 40 nM）。\ xa0还抑制fms样酪氨酸激酶4（VEGFR3，IC 50 = 110 nM）和表皮生
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CAS:1214265-56-1|WZ3146
作者：德尔塔 日期：2022-03-15
产品名称 WZ3146 英文名称 WZ3146 应用 A mutant EGFR phosphorylation inhibitor 规格或纯度 ≥98% 别名 WZ3146; WZ 3146 英文别名 WZ3146;WZ 3146;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide 运输条件 超低温冰袋运输 生化机理 WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del
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CAS:1213269-23-8|WZ4002
作者：德尔塔 日期：2022-03-15
产品名称 WZ4002 英文名称 WZ4002 应用 An EGFR phosphorylation inhibitor 规格或纯度 ≥98% 别名 WZ 4002; WZ-4002 生化机理 WZ 4002 is an inhibitor of EGFR phosphorylation in a variety of cancer cell lines including NIH-3T3 and H1975 cells. WZ 4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR.CAS编号 1213269-23-8
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CAS:1214265-57-2|WZ8040
作者：德尔塔 日期：2022-03-15
产品名称 WZ8040 英文名称 WZ8040 应用 A potent inhibitor of EGFR T790M 规格或纯度 ≥98% 别名 WZ-8040; WZ 8040 生化机理 WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ8040 treatment potently inhibits the growth of HCC827 (EGFR Del E746_A750), PC9 (EGFR Del E746_A750), H3255 (EGFR L858R), H1975 (EGFR L858R/T790M), and PC9 GR (EGFR Del E746_A750/T790M) with IC50 of 1 nM, 6 nM, 66 nM, 9 nM, and 8 nM, respectively. WZ8040 weakly inhibits the growth of HCC827 GR (EGFR E746_A750/MET amp), H1819 (ERBB2 amp), Calu-3 (ERBB2 amp), H1781 (ERBB2 I
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CAS:649735-63-7|Brivanib Alaninate (BMS-582664)
作者：德尔塔 日期：2022-03-15
产品名称 Brivanib Alaninate (BMS-582664) 英文名称 Brivanib Alaninate (BMS-582664) 规格或纯度 ≥95% 别名 Brivanib 丙氨酸酯;BMS582664 英文别名 BMS-582664; BMS 582664; BMS582664; (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester 运输条件 干冰运输CAS编号 649735-63-7
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CAS:649735-46-6|Brivanib (BMS-540215)
作者：德尔塔 日期：2022-03-15
产品名称 Brivanib (BMS-540215) 英文名称 Brivanib (BMS-540215) 应用 An ATP-competitive inhibitor against VEGFR-2, Flk-1, VEGFR-1 and FGFR-1 规格或纯度 ≥98% 别名 酪氨酸激酶抑制剂 生化机理 Brivanib is an ATP-competitive inhibitor against human VEGFR-2 and mouse Flk-1 with IC50 of 25 nM and 89 nM, respectively. Brivanib also inhibits VEGFR-1 and FGFR-1 with IC50 of 0.38 and 0.148 μM. Brivanib displays antitumor activities in H3396 xenograft. This compound completely inhibits the tumor growth, with TGI of 85% and 97%, respectively.CAS编号 649735-46-6
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CAS:212141-51-0|Vatalanib (PTK787) 2HCl
作者：德尔塔 日期：2022-03-15
产品名称 Vatalanib (PTK787) 2HCl 英文名称 Vatalanib (PTK787) 2HCl 规格或纯度 ≥99% 别名 瓦他拉尼二盐酸盐 英文别名 1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride；CGP 79787 dihydrochloride；CGP 79787D dihydrochloride；N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride；PTK787 dihydrochloride；ZK222584 dihydrochloride；Vatalanib 运输条件 超低温冰袋运输 生化机理 Vatalanib (PTK787) is a novel VEGFR and c-Kit tyrosine kinases and angiogenesis inhibitor with IC50 of 0.037, 0.077, 0.27 and 0.73 μM for KDR, Flt-1, Flk and c-Kit, resp
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