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「同位素标记抑制剂」Probucol-d6

「同位素标记抑制剂」Probucol-d6

作者:德尔塔生物 日期:2025-06-12

生物活性:Probucol-d6 is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Probucol-d6 相关抗体:S100A10 Antibody (YA675)分子量:522.88Formula:C31H42D6O2S2非标记 CAS:23288-49-5中文名称:普罗布考-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (530 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Probucol

「同位素标记抑制剂」Toremifene-d6 hydrochloride

「同位素标记抑制剂」Toremifene-d6 hydrochloride

作者:德尔塔生物 日期:2025-06-12

生物活性:Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].分子量:448.46Formula:C26H23D6Cl2NO非标记 CAS:89778-27-8中文名称:托瑞米芬盐酸盐-d6; 涛瑞米芬盐酸盐-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35. [Content Brief]

「同位素标记抑制剂」Toremifene-d6

「同位素标记抑制剂」Toremifene-d6

作者:德尔塔生物 日期:2025-06-12

生物活性:Toremifene-d6 is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Toremifene-d6 相关抗体:Estrogen Receptor alpha Antibody (YA768)Estrogen Receptor alpha AntibodyGPR30 AntibodyPBR Antibody (YA1785)REA Antibody (YA1848)Estrogen Related Receptor gamma Antibody (YA2009)ERR alpha Antibody (YA2283)Estrogen Receptor beta Antibody (YA1892)14-3-3 Antibody (YA1949)Estrogen Inducible Protein pS2 Antibody (YA2377)MVK Antibody (YA3093)分子量:412.00Formula:C26H22D6ClNO非标记 CAS:89778-26-7中文名称:托瑞米芬-d6; 涛瑞米芬-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Matthew R S

「同位素标记抑制剂」Nefazodone-d6 dihydrochloride

「同位素标记抑制剂」Nefazodone-d6 dihydrochloride

作者:德尔塔生物 日期:2025-06-12

生物活性:Nefazodone-d6 (dihydrochloride) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Nefazodone-d6 dihydrochloride 相关抗体:ADRB2 AntibodyMTNR1A AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量:548.97Formula:C25H28D6Cl3N5O2非标记 CAS:82752-99-6中文名称:萘法唑酮二盐酸盐-d6;二盐酸萘法唑酮-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (532 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Pullar IA, et al. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor an

「同位素标记抑制剂」Metalaxyl-d6

「同位素标记抑制剂」Metalaxyl-d6

作者:德尔塔生物 日期:2025-06-12

生物活性:Metalaxyl-d6 is the deuterium labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Metalaxyl-d6 相关抗体:SDHA Antibody分子量:285.37Formula:C15H15D6NO4非标记 CAS:57837-19-1中文名称:甲霜灵-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (533 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

「同位素标记抑制剂」Imidaprilate-d5

「同位素标记抑制剂」Imidaprilate-d5

作者:德尔塔生物 日期:2025-06-12

生物活性:Imidaprilate-d5 is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Imidaprilate-d5 相关抗体:ACE2 AntibodyACE AntibodyACE Antibody (YA2094)分子量:382.42Formula:C18H18D5N3O6非标记 CAS:89371-44-8中文名称:咪达普利拉-d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Kubo M, et al. Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53(2):201-10. [Content Brief]

「同位素标记抑制剂」Levodropropizine-d8

「同位素标记抑制剂」Levodropropizine-d8

作者:德尔塔生物 日期:2025-06-12

生物活性:Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Levodropropizine-d8 相关抗体:ADGRE1 (F4/80) Antibody (YA002)ADGRE1 (F4/80) Antibody (YA920)分子量:244.36Formula:C13H12D8N2O2非标记 CAS:99291-25-5中文名称:左羟丙哌嗪-d8运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19. [Content Brief]

「同位素标记抑制剂」Benzbromarone-d5

「同位素标记抑制剂」Benzbromarone-d5

作者:德尔塔生物 日期:2025-06-12

生物活性:Benzbromarone-d5 is deuterium labeled Benzbromarone.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Benzbromarone-d5 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量:429.11Formula:C17H7D5Br2O3非标记 CAS:3562-84-3中文名称:苯溴马隆-d5;苯溴马龙-d5;本补麻隆-d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (532 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

「同位素标记抑制剂」Ibutilide-d5 fumarate

「同位素标记抑制剂」Ibutilide-d5 fumarate

作者:德尔塔生物 日期:2025-06-12

生物活性:Ibutilide-d5 (fumarate) is deuterium labeled Ibutilide (fumarate).体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ibutilide-d5 fumarate 相关抗体:Annexin VI AntibodyCalbindin AntibodyCalreticulin AntibodyCardiac Troponin I/TNNC1 AntibodySCGN Antibody (YA1167)RAMP1 Antibody (YA1818)Annexin V Antibody (YA1829)Striatin 4 Antibody (YA2088)Fibulin 5 Antibody (YA2448)RASGRP1 Antibody (YA2546)Fibulin 1 Antibody (YA2831)EFEMP1 Antibody (YA2883)CRCP Antibody (YA3350)Annexin VII Antibody (YA1138)Parvalbumin Antibody (YA1249)Annexin IV Antibody (YA1921)SERCA2 ATPase Antibody (YA1931)Stromal Interaction Molecule 1 Antibody (YA2092)SERCA1 ATPase Antibody (YA2157)TrpV5 Antibody (YA2284)NCX1 Antibody (YA2331)Scramblase 1 Antibody (YA2419)CAB39 Antibody (YA2761)CUG BP1 Antibody (YA2806)C10orf63 Antibody (YA2894)ITPK1 Antibody (YA3125)ORAI3 Antibody (YA3128)ORAI1 Antibody (YA3157)CREB Regulated Transcription Coactivator 2 Antibody (YA3279)分子量:447.65Formula:C24H35D5N2O7S非标记 CAS:122647-32-9中文名称:富马酸伊布利特-d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (52

「同位素标记抑制剂」Milnacipran-d5 ((1S-cis) hydrochloride)

「同位素标记抑制剂」Milnacipran-d5 ((1S-cis) hydrochloride)

作者:德尔塔生物 日期:2025-06-12

生物活性:Milnacipran-d5 ((1S-cis) hydrochloride) is deuterium labeled Milnacipran ((1S-cis) hydrochloride).体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Milnacipran-d5 ((1S-cis) hydrochloride) 相关抗体:Serotonin Transporter Antibody (YA1638)HTR7 Antibody (YA2796)HTR2C Antibody (YA3364)分子量:287.84Formula:C15H18D5ClN2O非标记 CAS:175131-60-9中文名称:米那普仑-d5 ((1S-顺式)盐酸盐)运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

「同位素标记抑制剂」Piperacillin-d5

「同位素标记抑制剂」Piperacillin-d5

作者:德尔塔生物 日期:2025-06-12

生物活性:Piperacillin-d5 is deuterium labeled Piperacillin. Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins[1].IC50 & Target:β-lactam体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Piperacillin-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量:522.59Formula:C23H22D5N5O7S非标记 CAS:61477-96-1性状:固体颜色:White to off-white中文名称:哌拉西林-d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under n

「同位素标记抑制剂」17β-Estradiol-3-β-D-glucuronide-d3 sodium

「同位素标记抑制剂」17β-Estradiol-3-β-D-glucuronide-d3 sodium

作者:德尔塔生物 日期:2025-06-12

生物活性:17β-Estradiol-3-β-D-glucuronide-d3 (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide[1].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量:473.51Formula:C24H28D3NaO8性状:固体颜色:White to off-white运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度: 98.19%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

「同位素标记抑制剂」Sotorasib-d7

「同位素标记抑制剂」Sotorasib-d7

作者:德尔塔生物 日期:2025-06-12

生物活性:Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib (HY-114277). Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC)[1][2][3].IC50 & Target:KRAS(G12C)体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sotorasib-d7 相关抗体:Rab5 AntibodyRAB8A AntibodyEpac1 AntibodyGRB2 AntibodyRAB7 AntibodyRas AntibodyRASA1 AntibodyRhoA Antibody (YA093)RhoA AntibodyRhoA/B/C AntibodyRab10 Antibody (YA1789)Rab7B Antibody (YA1798)Rab9 Antibody (YA1800)GTPase NRAS Antibody (YA1830)GTPase HRAS Antibody (YA1833)Rab4 Antibody (YA2272)IQGAP1 Antibody (YA2388)G3BP Antibody (YA2432)GPRC5B Antibody (YA2964)Rab11A Antibody (YA2976)Rac Antibody (YA3290)SOS1 Antibody (YA3313)CDC42EP1 AntibodyRAB5C AntibodyGRB2 Antibody (YA748)Rab22A Antibody (YA1791)Rab45 Antibody (YA1792)Rac3 Antibody (YA1802)RALB Antibody (YA1816)Rab25 Antibody (YA1881)分子量:567.64Formula:C30H23D7F2N6O3非标记 CAS:2296729-00-3性状:固体颜色:White to off-white中文名称:索托拉西布-d7运输条件:Room temperature in continental US; may vary elsewhere.储存方式:-20°C, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (stored unde

「同位素标记抑制剂」Clarithromycin-13C,d3

「同位素标记抑制剂」Clarithromycin-13C,d3

作者:德尔塔生物 日期:2025-06-12

生物活性:Clarithromycin-13C,d3 is the deuterium and 13C labeled Clarithromycin[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Clarithromycin-13C,d3 相关抗体:Cytochrome C AntibodyCytochrome P450 17A1 AntibodyAromatase AntibodyMRP2 AntibodyCYP11A1 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Cytochrome P450 1B1 Antibody (YA1836)Adrenodoxin Antibody (YA2005)Cytochrome P450 27A1 Antibody (YA2163)Cytochrome P450 2C9 Antibody (YA2166)Cytochrome P450 2E1 Antibody (YA2302)Cytochrome P450 Reductase Antibody (YA2619)Thromboxane A Synthase Antibody (YA2670)Cytochrome P450 3A4 Antibody (YA3365)HSD11B1 Antibody (YA3376)Cytochrome P450 17A1 Antibody (YA786)Sulfadimidine Antibody (YA906)CYP2E1 AntibodyCYP1A2 AntibodyElongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)PLSCR3 Antibody (YA1672)PROX1 Antibody (YA1754)Elongation factor 1 gamma Antibody (YA2004)Cytochrome P450 4A Antibody (YA2087)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cytochrome P450 24A1 Antibody (YA2121)Cytochrome P450 26A1 Antibody (YA2259)分子量:751.96Formula:C3713CH66D3NO13非标记 CAS:81103-11-9性状:固体颜色:White to off-white中文名称:克拉

「同位素标记抑制剂」Tecovirimat-d4

「同位素标记抑制剂」Tecovirimat-d4

作者:德尔塔生物 日期:2025-06-12

生物活性:Tecovirimat-d4 (ST-246-d4) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases[1][2][3][4][5].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量:380.35Formula:C19H11D4F3N2O3非标记 CAS:869572-92-9性状:固体颜色:White to off-white运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month