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「同位素标记抑制剂」CAS:1346598-22-8|Belotecan-d7 hydrochloride
作者：德尔塔生物 日期：2025-09-19
生物活性：Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Belotecan-d7 hydrochloride 相关抗体:TOP2A AntibodyDXd Antibody (YA897)SN38 Antibody (YA923)Topoisomerase I Antibody (YA2237)分子量：477.00Formula：C25H21D7ClN3O4CAS 号：1346598-22-8非标记 CAS：213819-48-8性状：固体颜色：White to off-white中文名称：盐酸贝洛替康 d7 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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「同位素标记抑制剂」CAS:1185112-19-9|4-Hydroxytolbutamide-d9
作者：德尔塔生物 日期：2025-09-19
生物活性：4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.4-Hydroxytolbutamide-d9 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：295.40Formula：C12H9D9N2O4SCAS 号：1185112-19-9非标记 CAS：5719-85-7性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2260669-28-9|β-Sitosterol-d7 (Mixture of Diastereomers)
作者：德尔塔生物 日期：2025-09-19
生物活性：β-Sitosterol-d7 (Mixture of Diastereomers) is the deuterium labeled β-Sitosterol (mixture of diasteromers)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：421.75Formula：C29H43D7OCAS 号：2260669-28-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1185242-90-3|Mycophenolic acid-d3
作者：德尔塔生物 日期：2025-09-19
生物活性：Mycophenolic acid-d3 is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.分子量：323.36Formula：C17H17D3O6CAS 号：1185242-90-3非标记 CAS：24280-93-1性状：固体颜色：White to off-white中文名称：霉酚酸 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:89924-82-3|Cyclopropylcarboxylic acid-d4
作者：德尔塔生物 日期：2025-09-19
生物活性：Cyclopropylcarboxylic acid-d4 is the deuterium labeled Cyclopropylcarboxylic acid[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：90.11Formula：C4H2D4O2CAS 号：89924-82-3非标记 CAS：1759-53-1性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」iso-Nadolol (tert-Butyl-d9)
作者：德尔塔生物 日期：2025-09-19
生物活性：iso-Nadolol (tert-Butyl-d9) is the deuterium labeled iso-Nadolol (tert-Butyl)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：318.46Formula：C17H18D9NO4CAS 号：1246820-10-9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」Granisetron-d3
作者：德尔塔生物 日期：2025-09-19
生物活性：Granisetron-d3 is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].细胞效力(Cellular Effect)HEK293Cell Line TypeValueDescriptionReferencesHEK293EC500.32 μMCompound: Granisetron, KutrilAgonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells by FLIPR assay[PMID: 24128813]HEK293EC500.5 μMCompound: Granisetron, KutrilAgonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells by FLIPR assayAgonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells by FLIPR assay[PMID: 24128813]HEK293IC50311 μMCompound: granisetronInhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayInhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay[PMID: 23241029]HEK293IC504.3 μMCompound: granisetronInhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayInhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay[PMID: 23241029]HEK293IC505 μMCompound: granisetronInhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayInhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay[PMID: 23241029]体外研究(
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「同位素标记抑制剂」Homo Sildenafil-d5
作者：德尔塔生物 日期：2025-09-19
生物活性：Homo Sildenafil-d5 is the deuterium labeled Homo Sildenafil. Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Homo Sildenafil-d5 相关抗体:PDE1B Antibody (YA1553)PDE4B Antibody (YA2932)PDE2A Antibody (YA2989)PDE4D Antibody (YA1714)分子量：493.63Formula：C23H27D5N6O4SCAS 号：1216711-61-3非标记 CAS：642928-07-2中文名称：豪莫西地那非-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Jackie D Corbin, et al. Vardenafil: Structural Basis for Higher Potency Over Sildenafil in Inhibiting cGMP-specific phosphodiesterase-5 (PDE5). Neurochem Int. 2004 Nov;45(6):859-63. [Content Brief]
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「同位素标记抑制剂」Pimozide-d5 N-Oxide
作者：德尔塔生物 日期：2025-09-19
生物活性：Pimozide-d5 N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].IC50 & Target：D1 ReceptorD3 Receptor体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pimozide-d5 N-Oxide 相关抗体:FOXP3 Antibody (YA858)Phospho-STAT3 (Tyr705) Antibody (YA146)STAT3 Antibody (YA056)Phospho-STAT1 (Ser727) Antibody (YA148) Phospho-STAT1 (Tyr701) AntibodyPhospho-STAT3 (Tyr705) AntibodyFOXP3 AntibodyPhospho-STAT3 (Ser727) AntibodySTAT1 Antibody (YA059)STAT1 Antibody (YA667)STAT1 alpha AntibodySTAT2 Antibody (YA057)STAT5a AntibodySTAT5b AntibodySTAT6 AntibodyPhospho-STAT5 (Tyr694) Antibody (YA145)FOXP3 Antibody (YA759)Phospho-STAT1 (Ser727) Antibody (YA149) STAT3 Antibody (YA666)STAT4 AntibodySTAT5 AntibodyADRB2 AntibodyDRD2 AntibodyPhospho-STAT5(Tyr694) Antibody (YA1513)Dopamine Receptor D3 Antibody (YA1742)DOPA Decarboxylase Antibody (YA2428)Dopamine Receptor D1 Antibody (YA3270)Salbutamol Antibody (YA901)Clenbuterol Antibody (YA904)T-bet / Tbx21 Antibody (YA1217)分子量：482.58Formula：C28H24
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「同位素标记抑制剂」Phentolamine-d4 hydrochloride
作者：德尔塔生物 日期：2025-09-19
生物活性：Phentolamine-d4 (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Phentolamine-d4 hydrochloride 相关抗体:ADRB2 AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量：285.38Formula：C17H16D4ClN3OCAS 号：1346599-65-2非标记 CAS：73-05-2中文名称：甲磺酸酚妥拉明-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (535 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Gould L, et, al. Phentolamine. Am Heart J. 1976 Sep;92(3):397-402. [Content Brief][3]. Goldstein I, et, al
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「同位素标记抑制剂」(±)-Lisofylline-d6
作者：德尔塔生物 日期：2025-09-19
生物活性：(±)-Lisofylline-d6 is the deuterium labeled (±)-Lisofylline[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：286.36Formula：C13H14D6N4O3CAS 号：1185995-26-9非标记 CAS：6493-06-7中文名称：(±)-利索茶碱-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」(rac)-Viloxazine-d5 hydrochloride
作者：德尔塔生物 日期：2025-09-19
生物活性：(rac)-Viloxazine-d5 (hydrochloride) is the deuterium labeled (rac)-Viloxazine hydrochloride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：278.79Formula：C13H15D5ClNO3CAS 号：1276483-10-3非标记 CAS：35604-67-2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」Lovastatin-d3 hydroxy acid sodium
作者：德尔塔生物 日期：2025-09-19
生物活性：Lovastatin-d3 hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Lovastatin-d3 hydroxy acid sodium 相关抗体:HMGCS2 AntibodyHMGB1 AntibodyHMGCR AntibodyBaf180 Antibody (YA1176)BANF1 Antibody (YA1740)LEF1 Antibody (YA3164)HMGA1 Antibody (YA1185)HMGA2 Antibody (YA1186)Baf57 Antibody (YA2110)HMGN2 Antibody (YA2839)HMG4 Antibody (YA2992)HMGB2 Antibody (YA2995)HMGCL Antibody (YA3024)分子量：447.56Formula：C24H35D3NaO6CAS 号：1217528-38-5非标记 CAS：75225-50-2中文名称：洛伐他汀EP杂质B Sodium Salt (Lovastatin Hydroxy Acid Sodium Salt)-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethyl
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「同位素标记抑制剂」Bempedoic acid-d5
作者：德尔塔生物 日期：2025-09-19
生物活性：Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Bempedoic acid-d5 相关抗体:AMPK alpha AntibodyPhospho-AMPK alpha 2 (Thr172) AntibodyAMPK alpha 2 Antibody (YA833)Phospho-AMPK alpha 2(Ser345) AntibodyAMPK alpha 1 AntibodyAMPK alpha 1 Antibody (YA624)ATP citrate lyase AntibodyPhospho-AMPK alpha 1 (Ser496) Antibody (YA226)Phospho-Hormone sensitive lipase (Ser853) AntibodyATF4 Antibody (YA605)AMPK alpha 2 Antibody (YA623)AMPK beta 1 AntibodyAMPK gamma 1 AntibodyATF4 AntibodyATP Citrate Lyase Antibody (YA829)Phospho-AMPK alpha 1 (Ser496) AntibodyMARK2 Antibody (YA2104)MARK3 Antibody (YA2150)Phospho-Hormone Sensitive Lipase (Ser855) Antibody (YA2599)分子量：349.52Formula：C19H31D5O5CAS 号：2408131-71-3非标记 CAS：738606-46-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (522 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of
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「同位素标记抑制剂」Ricinine-d3
作者：德尔塔生物 日期：2025-09-19
生物活性：Ricinine-d3 is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：167.18Formula：C8H5D3N2O2CAS 号：1313734-77-8非标记 CAS：524-40-3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Oriakhi K, et al. Isolation, characterization, and hepatoprotective properties of betulinic acid and ricinine from Tetracarpidium conophorum seeds (Euphorbiaceae). J Food Biochem. 2021;45(3):e13288. [Content Brief]
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