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CAS:166447-71-8|(E,​E​-​Farnesol-d6,(E,​E​-​法呢醇-d6; trans,trans-Farnesol-d6;  (2E,6E-Farnesol-d6

CAS:166447-71-8|(E,​E​-​Farnesol-d6,(E,​E​-​法呢醇-d6; trans,trans-Farnesol-d6; (2E,6E-Farnesol-d6

作者:德尔塔生物 日期:2025-07-08

生物活性:(E,​E)​-​Farnesol-d6 is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(E,​E)​-​Farnesol-d6 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量:228.40Formula:C15H20D6OCAS 号:166447-71-8非标记 CAS:106-28-5性状:液体颜色:Light yellow to yellow中文名称:(E,​E)​-​法呢醇-d6; (E,​E)​-​金合欢醇-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Pure form-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month纯度 & 产

CAS:1020719-62-3|Pirfenidone-d5,AMR69-d5

CAS:1020719-62-3|Pirfenidone-d5,AMR69-d5

作者:德尔塔生物 日期:2025-07-08

生物活性:Pirfenidone-d5 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].IC50 & Target:TGF-β2[1][2]CCL2 and CCL12[3]分子量:190.25Formula:C12H6D5NOCAS 号:1020719-62-3非标记 CAS:53179-13-8性状:固体颜色:White to light yellow中文名称:吡非尼酮 d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:2699608-18-7|Acalabrutinib-d4,ACP-196-d4

CAS:2699608-18-7|Acalabrutinib-d4,ACP-196-d4

作者:德尔塔生物 日期:2025-07-08

生物活性:Acalabrutinib-d4 is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.分子量:469.53Formula:C26H19D4N7O2CAS 号:2699608-18-7非标记 CAS:1420477-60-6性状:固体颜色:Light yellow to light brown运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:1189805-51-3|(±-Levomepromazine-d6,(±-Methotrimeprazine-d6; dl-Methotrimeprazine-d6

CAS:1189805-51-3|(±-Levomepromazine-d6,(±-Methotrimeprazine-d6; dl-Methotrimeprazine-d6

作者:德尔塔生物 日期:2025-07-08

生物活性:(±)-Levomepromazine-d6 is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.分子量:334.51Formula:C19H18D6N2OSCAS 号:1189805-51-3非标记 CAS:851-68-3性状:固体颜色:White to yellow中文名称:(±)-左美丙嗪-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:1346599-45-8|Azilsartan-d5,阿齐沙坦D5; TAK-536-d5

CAS:1346599-45-8|Azilsartan-d5,阿齐沙坦D5; TAK-536-d5

作者:德尔塔生物 日期:2025-07-08

生物活性:Azilsartan-d5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.分子量:461.48Formula:C25H15D5N4O5CAS 号:1346599-45-8非标记 CAS:147403-03-0性状:固体颜色:White to off-white中文名称:阿齐沙坦 d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:2 years-20°C:1 year

CAS:1414348-52-9|D-Serine-d3,D-丝氨酸-d3; (R-Serine-d3

CAS:1414348-52-9|D-Serine-d3,D-丝氨酸-d3; (R-Serine-d3

作者:德尔塔生物 日期:2025-07-08

生物活性:D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.D-Serine-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyPSD95 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNMDAR1 AntibodyNMDAR2A AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量:108.11Formula:C3H4D3NO3CAS 号:1414348-52-9非标记 CAS:312-84-5性状:固体颜色:White to off-white中文名称:D-丝氨酸-d3运输条件:Room temperature in continental US; may vary elsewhere.储存方式:-20°C, stored under nitrogen*In solvent : -80°C, 6

CAS:1133387-60-6|Aprepitant-d4,阿瑞匹坦-d4

CAS:1133387-60-6|Aprepitant-d4,阿瑞匹坦-d4

作者:德尔塔生物 日期:2025-07-08

生物活性:Aprepitant-d4 is the deuterium labeled Aprepitant[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量:538.45Formula:C23H17D4F7N4O3CAS 号:1133387-60-6非标记 CAS:170729-80-3性状:固体颜色:White to off-white中文名称:阿瑞匹坦-d4;阿瑞吡坦-d4;阿瑞比坦-d4运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:1261396-79-5|Hydrochlorothiazide-13C6,HCTZ-13C6

CAS:1261396-79-5|Hydrochlorothiazide-13C6,HCTZ-13C6

作者:德尔塔生物 日期:2025-07-08

生物活性:Hydrochlorothiazide-13C6 is the 13C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Hydrochlorothiazide-13C6 相关抗体:Smad3 AntibodyTGF beta 1 AntibodySmad1 AntibodySmad2 AntibodySmad4 AntibodySmad5 AntibodyPhospho-Smad3 (Ser423/Ser425) AntibodyATP1A1 AntibodyCD105 Antibody (YA547)Noggin Antibody (YA698)Phospho-Smad1 (Ser463/Ser465) AntibodyPhospho-Smad2 (Ser250) AntibodyPhospho-Smad3 (Ser423/425) AntibodySmad2/3 AntibodyInhibin beta A Antibody (YA2780)Phospho-Smad5 (Ser463/465) Antibody (YA2838)LGI1 Antibody (YA2885)Inhibin alpha Antibody (YA1232)Inhibin beta B Antibody (YA1677)Cardiac Troponin C Antibody (YA2125)Phospho-NDRG1 (Ser330) Antibody (YA2618)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)SARA Antibody (YA3226)分子量:303.70Formula:C13C6H8ClN3O4S2CAS 号:1261396-79

CAS:119176-67-9|Azelaic acid-d14,Nonanedioic acid-d14

CAS:119176-67-9|Azelaic acid-d14,Nonanedioic acid-d14

作者:德尔塔生物 日期:2025-07-08

生物活性:Azelaic acid-d14 is the deuterium labeled Azelaic acid[1]. Azelaic acid is an organic compound produced by the ozonolysis of oleic acid;component of a number of hair and skin conditioners[2][3].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Azelaic acid-d14 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量:202.31Formula:C9H2D14O4CAS 号:119176-67-9非标记 CAS:123-99-9性状:固体颜色:White to yellow中文名称:壬二酸-d14;杜鹃花酸-d14运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:2086337-18-8|Hypoxanthine-13C5,Purin-6-ol-13C5;  Sarcine-13C5

CAS:2086337-18-8|Hypoxanthine-13C5,Purin-6-ol-13C5; Sarcine-13C5

作者:德尔塔生物 日期:2025-07-08

生物活性:Hypoxanthine-13C5 is a 13C-labeled H-Lys-OH.2HCl[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Hypoxanthine-13C5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量:141.07Formula:13C5H4N4OCAS 号:2086337-18-8非标记 CAS:68-94-0性状:固体颜色:White to off-white运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:718612-49-8|SN-38-d3,NK012-d3

CAS:718612-49-8|SN-38-d3,NK012-d3

作者:德尔塔生物 日期:2025-07-08

生物活性:SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.SN-38-d3 相关抗体:TOP2A AntibodyDXd Antibody (YA897)MMAE Antibody (YA899)MMAF Antibody (YA900)SN38 Antibody (YA923)Topoisomerase I Antibody (YA2237)分子量:395.42Formula:C22H17D3N2O5CAS 号:718612-49-8非标记 CAS:86639-52-3性状:固体颜色:Off-white to light yellow运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:161096-83-9|2-Ketoglutaric acid-13C5,α-酮戊二酸-13C5

CAS:161096-83-9|2-Ketoglutaric acid-13C5,α-酮戊二酸-13C5

作者:德尔塔生物 日期:2025-07-08

生物活性:2-Ketoglutaric acid-13C5 is the 13C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2-Ketoglutaric acid-13C5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMiTF AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)ZAP70 Antibody (YP4051)Asparagine Synthetase AntibodyCalnexin AntibodyCD3 epsilon AntibodyCD3D AntibodyKi67 Antibody (YA001)分子量:151.06Formula:13C5H6O5CAS 号:161096-83-9性状:固体颜色:White to off-white中文名称:α-酮戊二酸-13C5运输条件:Room temperature in continental US; may vary elsewhere.储

CAS:14314-42-2|Water-18O

CAS:14314-42-2|Water-18O

作者:德尔塔生物 日期:2025-07-08

生物活性:Water-18O is the 18O-labeled Water[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量:20.02Formula:H218OCAS 号:14314-42-2非标记 CAS:7732-18-5性状:液体(密度:1.11 g/cm3)颜色:Colorless to light yellow运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Pure form-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month纯度 & 产品资料纯度: 99.99%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]

CAS:121662-14-4|Ibuprofen-d3,氘代布洛芬; (±-Ibuprofen-d3

CAS:121662-14-4|Ibuprofen-d3,氘代布洛芬; (±-Ibuprofen-d3

作者:德尔塔生物 日期:2025-07-08

生物活性:Ibuprofen-d3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ibuprofen-d3 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量:209.30Formula:C13H15D3O2CAS 号:121662-14-4非标记 CAS:15687-27-1性状:固体颜色:White to off-white中文名称:布洛芬 d3 杂质82运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

CAS:360768-37-2|N-Ethylmaleimide-d5,N-乙基马来酰亚胺 d5; NEM-d5

CAS:360768-37-2|N-Ethylmaleimide-d5,N-乙基马来酰亚胺 d5; NEM-d5

作者:德尔塔生物 日期:2025-07-08

生物活性:N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.N-Ethylmaleimide-d5 相关抗体:Cathepsin B AntibodyCathepsin D AntibodyPGP9.5 AntibodyUSP7 Antibody (YA657)Cathepsin K AntibodyUSP28 Antibody (YA1336)UCHL5 Antibody (YA2339)USP10 Antibody (YA2362)Cathepsin L/V/K/H Antibody (YA2547)UCHL3 Antibody (YA2811)USP14 Antibody (YA3328)Ataxin 3 Antibody (YA1294)USP22 Antibody (YA1334)OTUB1 Antibody (YA1483)Cathepsin S Antibody (YA1614)USP9X Antibody (YA1811)USP11 Antibody (YA1846)ADRM1 Antibody (YA2007)Ataxin 1 Antibody (YA2177)USP13 Antibody (YA2367)Cathepsin Z Antibody (YA2382)BAP1 Antibody (YA2733)分子量:130.16Formula:C6H2D5NO2CAS 号:360768-37-2非标记 CAS:128-53-0性状:固体颜色:White to off-white中文名称:N-乙基马来酰亚胺 d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month