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「同位素标记抑制剂」Sofosbuvir-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.分子量：535.49Formula：C22H23D6FN3O9PCAS 号：1868135-06-1非标记 CAS：1190307-88-0性状：固体颜色：White to off-white中文名称：索非布韦 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」4’-Hydroxy Flurbiprofen-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：4’-Hydroxy Flurbiprofen-d3 is the deuterium labeled 4’-Hydroxy Flurbiprofen[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：263.28Formula：C15H10D3FO3CAS 号：1189694-02-7性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Tetrabenazine-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590), is the first deuterium approved worldwide for the research of Huntington's disease, or other hyperkinetic movement disorders[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。氘代化合物的潜在优势：（1）延长体内半衰期。氘代化合物或能够延长化合物的药代动力学特征，即延长体内半衰期。由此可提高化合物安全性、有效性和耐受性，并增加给药的便捷性。（2）提高口服生物利用度。氘代化合物或能够减少肠壁和肝脏中不需要的代谢 (首过代谢) 程度，使得更大比例的未代谢药物到达作用的目标位置。生物利用度高决定其在低剂量下具有活性以及更好的耐受性。（3）改善代谢特征。氘代化合物或能够减少有毒或反应性代谢物的形成，改善药物代谢状况。（4）改进药品安全性。氘代化合物或能够减少或消除药物化合物的不良副作用，具有安全性。（5）保留治疗特性。氘代化合物有望保留和此前研究中氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT04173260University of Pennsylvania|Teva Branded Pharmaceutical Products R&D, Inc.Dystonia, PrimaryAugust 6, 2020Phase 1|Phase 2NCT04071639Second Affiliated Hospital, School of Medicine, Zhejiang UniversityHuntington DiseaseMarch 12, 2020Phase 1NCT04301726Fundacion Huntington Puerto RicoHuntington DiseaseSeptember 1, 2020Phase 1 NCT04713982Vanderbilt University Medical Center|Teva Branded Pharmaceutical Products R&D, Inc.Huntington DiseaseNovember
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「同位素标记抑制剂」Fexofenadine-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Fexofenadine-d6 is deuterium labeled Fexofenadine, which is an antihistamine pharmaceutical agent.分子量：507.69Formula：C32H33D6NO4CAS 号：548783-71-7非标记 CAS：83799-24-0性状：固体颜色：White to off-white中文名称：非索非那定 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」MES-d13
作者：德尔塔生物 日期：2025-09-18
生物活性：MES-d13 is the deuterium labeled MES. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.MES-d13 相关抗体:Mouse IgG Isotype Control6X His-tag (C-terminal) Antibody (YA860)DYKDDDDK Tag (FLAG) AntibodyGFP AntibodyMyc-tag AntibodyHA tag Antibody (YA856)GST-Tag Antibody HRP ConjugatedV5-tag AntibodyCollagen I alpha 2 AntibodyRabbit IgG Isotype Control6X His Tag (C-terminal) AntibodyHis Tag Antibody (HRP) (YA877)HA Tag Antibody (HRP) (YA876)EYFP Tag Antibody (YA872)HSV Tag Antibody (YA878)MBP Tag Antibody (YA879)RFP Tag Antibody (YA882)S Tag Antibody (YA883)SRT Tag Antibody (YA884)Strep-Tag II Antibody (YA885)TAP Tag Antibody (YA887)Collagen II AntibodyCollagen III AntibodyCollagen X AntibodyCollagen IV AntibodyCollagen I AntibodyCollagen VI alpha 1/2/3 Antibody (YA2637)AmCyan Tag Antibody (YA864)DsbA Tag Antibody (YA868)E2 Tag Antibody (YA870)分子量：208.32Formula：C6D13NO4SCAS 号：352534-94-2非标记 CAS
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「同位素标记抑制剂」Glycerol-d8
作者：德尔塔生物 日期：2025-09-18
生物活性：Glycerol-d8 is the deuterium labeled Glycerol[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：100.14Formula：C3D8O3CAS 号：7325-17-9性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」4-Hydroxynonenal-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].IC50 & Target：ALDH2体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.4-Hydroxynonenal-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)ALDH1A1 AntibodyAsparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibo
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「同位素标记抑制剂」Mirtazapine-d3
作者：德尔塔生物 日期：2025-09-18
生物活性：Mirtazapine-d3 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].IC50 & Target[1]：5-HT2 Receptor5-HT3 Receptor体内研究(In Vivo)米氮平 (腹膜内注射；10-50 mg/Kg；14 天) 处理可使心率、呼吸率、焦虑水平正常化并消除在 MeCP2 缺失小鼠中观察到的跳跃行为，从而改善表型评分[2]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Animal Model:MeCP2 null mice[2]Dosage:10-50 mg/KgAdministration:Intraperitoneal injection; 10-50 mg/Kg; 14 daysResult:Restored the thickness of MeCP2-null mice somatosensory cortex, especially of layers II-III and VI.分子量：268.38Formula：C17H16D3N3CAS 号：1216678-68-0非标记 CAS：85650-52-8性状：固体颜色：White to off-white中文名称：米氮平杂质13 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」Abscisic acid-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Abscisic acid-d6 相关抗体:PMCA1 Antibody (YA1676)分子量：270.36Formula：C15H14D6O4CAS 号：721948-65-8非标记 CAS：21293-29-8性状：固体颜色：White to off-white中文名称：(+)-脱落酸-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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「同位素标记抑制剂」Cabazitaxel-d6
作者：德尔塔生物 日期：2025-09-18
生物活性：Cabazitaxel-d6 is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cabazitaxel-d6 相关抗体:alpha Tubulin AntibodyLC3A/B AntibodyBeta Tubulin Antibodybeta Tubulin Antibody (YA839)Doublecortin AntibodyLC3B Antibody (YA308)Stathmin 1 Antibody (YA049)Stathmin 1 Antibody (YA050)alpha Tubulin (acetyl K40) Antibodybeta III Tubulin Antibodygamma Tubulin AntibodyLC3B AntibodyBeta Tubulin Antibody (HRP) (YA865)Cytokeratin 5 AntibodyMAP2 AntibodyDM1 Antibody (YA898)CK18 AntibodyCytokeratin 19 AntibodyCytokeratin 7 Antibody (YA951)Cytokeratin 15 Antibody (YA1493)p63 Antibody (YA1531)Cytokeratin 6 Antibody (YA1701)Cytokeratin 4 Antibody (YA1762)Cytokeratin 10 Antibody (YA1857)Cytokeratin 14 Antibody (YA1876)Cytokeratin 1 Antibody (YA2665)Stanniocalcin 1 Antibody (YA2690)Cytokeratin 13 Antibody (YA2695)HRH3 Antibody (YA2701)Phospho-alpha Tubulin (Tyr272) Antibody (YA3041)分子量：841.97Formula：C45H51D6NO14CAS 号：1383561-29-2非标记 CAS：183133-96-2性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Sulfamonomethoxine-d3，磺胺间甲氧嘧啶钠 d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-18
生物活性：Sulfamonomethoxine-d3 is the deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sulfamonomethoxine-d3 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：283.32Formula：C11H9D3N4O3S非标记 CAS：1220-83-3中文名称：磺胺间甲氧嘧啶钠 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al.
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Fmoc-L-Val-OH-13C5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-18
生物活性：Fmoc-L-Val-OH-13C5 is a 13C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：344.35Formula：C1513C5H21NO4非标记 CAS：68858-20-8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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24-Methylenecholesterol-13C，Ostreasterol-13C「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-18
生物活性：24-Methylenecholesterol-13C (Ostreasterol-13C) is the 13C labeled 24-Methylenecholesterol (HY-133968)[1]. 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth[2][3][4].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.24-Methylenecholesterol-13C 相关抗体:Catalase Antibody (YA552)Catalase Antibody (YA811)DGAT1 AntibodyC Reactive Protein Antibody (YA941)PARK7/DJ1 Antibody (YA1799)ACOX1 Antibody (YA1979)C Reactive Protein Antibody (YA939)C Reactive Protein Antibody (YA940)ABHD5 Antibody (YA1108)PON1 Antibody (YA1666)PON2 Antibody (YA1688)ACAT1 Antibody (YA1971)分子量：399.66Formula：C2713CH46O非标记 CAS：474-63-5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (544 KB)产品使用指南 (1538 KB)参考文献[1]. Russa
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3-O-Methyldopa-d3 hydrate，3-Methoxy-L-tyrosine-d3 hydrate; 3-O-Methyl-L-DOPA-d3 hydrate「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-18
生物活性：3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.3-O-Methyldopa-d3 hydrate 相关抗体:IL-1 beta AntibodyEpCAM Antibody (YA772)IL-1 beta Antibody (YA345)CD127 AntibodyEpCAM Antibody (YA458)IL-18 AntibodyIL-4 Antibody (YA343)IL-6 AntibodySOCS1 AntibodyIL-8/CXCL8 AntibodyIL-10 AntibodyIL17A AntibodyIL-1 alpha AntibodyIL-6R AntibodyIL-13 Receptor alpha 1 Antibody (YA1624)FMO3 Antibody (YA1992)IL-12 beta Antibody (YA2753)IL-32 Antibody (YA2911)IL-11 Receptor alpha Antibody (YA3092)SOCS2 AntibodyCEACAM1 AntibodyCEA Antibody (YA917)IL-19 AntibodyIL-4I1/LAO Antibody (YA1225)IL-5 Receptor alpha Antibody (YA1228)SIRP alpha Antibody (YA1361)IL-13RA1 Antibody (YA1377)IL-17RA Antibo
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Fenoprofen-13C6 sodium hydrate，LILLY-53858-13C6 sodium hydrate「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-18
生物活性：Fenoprofen-13C6 (LILLY-53858-13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2][3].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Fenoprofen-13C6 sodium hydrate 相关抗体:ERK1/2 AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) AntibodyPhospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)COX2 AntibodyERK2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyERK5 AntibodyERK1 AntibodyKGF AntibodyPhospho-ERK1/2 (Thr202/Thr185) AntibodyPhospho-ERK1/2 (Tyr204/Tyr187) AntibodyCOX IV Antibody (YA867)CTGF Antibodyphospho-ERK1 + 2 (Thr183/Tyr185) AntibodyFAP Antibody (YA1090)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)Folate Binding Protein Antibody (YA1099)FRS2 Antibody (YA1400)MC4R Antibody (YA1645)Frizzled 9 Antibody (YA1930)MC1R Antibody (YA2019)Frizzled 8 Antibody (YA2052)Glutathione Peroxidase 2 Antibody (YA2153)FIG4 Antibody (YA2516)Fetal Hemoglobin Antibody (YA2564)FHIT Antibody (YA2677)ELK1 Antibody (YA2758)Fetuin A Antibody (YA2824)分
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