【产品介绍】：

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B re..产品名称：RS127445 纯度：99% min CAS NO：199864-87-4 溶解度：DMSO : ≥ 31 mg/mL (97.55 mM) 分子式：C17H17ClFN3 包装：可按客户要求包装。 分子量：317.788 贮存：-20℃RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5+/-0.1) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. RS-127445 potently antagonized 5-HT-evoked formation of inositol phosphates (pK(B) = 9.5+/-0.1) and 5-HT-evoked increases in intracellular calcium (pIC50 = 10.4+/-0.1). RS-127445 also blocked 5-HT-evoked contraction of rat isolated stomach fundus (pA2 = 9.5+/-1.1) and (+/-)alpha-methyl-5-HT-mediated relaxation of the rat jugular vein (pA2 = 9.9+/-0.3).   中文名称： 4-(4-氟-1-萘)-6-(1-甲基乙基)-2-嘧啶胺盐酸盐   物化属性: 密度：1.213 沸点：472.8°C at 760 mmHg 折射率：1.637 闪光点：239.8°C 储存条件：Desiccate at +4°C PSA：51.80000 LOGP：5.52470