【产品介绍】：

中文别名 T Tc-99m tilmanocept 英文别名 Technetium Tc-99m tilmanocept CAS号 1262984-82-6 SMILES Not Available Inchi InchiKey 分子式 Formula Not Available 分子量 Molecular Weight Not Available 闪点 FP NA 熔点 Melting point NA 沸点 Boiling point NA Polarizability极化度 密度 Density NA 蒸汽压 Vapor Pressure 溶解度Solubility 性状 NA 储藏条件 Storage conditions Technetium Tc-99m tilmanocept使用注意事项：1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。5.取药品时尽量采用多个药勺分别使用，使用后清洗干净。6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。大规格定制：定制产品请将信息发送至sales@bio-fount.com。Experimental considerations: 1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment. 2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution. 产品说明 Technetium Tc-99m tilmanocept is a radiopharmaceutical diagnostic imaging agent approved by the U.S. Food and Drug Administration (FDA) for the imaging of lymph nodes with or without scintigraphic imaging. It is a macromolecule consisting of multiple units of diethylenetriaminepentaacetic acid (DTPA) and mannose, each covalently attached to a 10 kDa dextran backboneLabel. DTPA serves as a chelating agent for technetium Tc 99m to bindLabel. Technetium Tc-99m tilmanocept is used in lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors2,3. Detecting sentinel lymph node (SLN) is clinically useful in the prognosis and management of the disease, as it is considered as the first lymph node that receives afferent lymphatic drainage from a primary tumor, and may be used to predict tumour staging and metastasis3. However, as nodal micrometastasis in breast cancer may not be associated with significant changes in survival, it is also important to identify clinically node-negative patients3.Technetium Tc-99m tilmanocept is a novel CD206 receptor-targeted molecule that selectively binds to mannose receptors expressed on the surface of reticuloendothelial cells in lymph nodes1. Due to its relatively small molecular weight and small molecular diameter of 7 nm1, technetium Tc-99m tilmanocept displays more rapid injection site clearance, high sentinel node extraction, and low distal node accumulation compared to other conventional radiocolloids3. It achieves high overall accuracy in detecting SLN2. Once reconstituted and labelled, technetium Tc99m tilmanocept is intended to be injected in close proximity to the tumor being diagnosed and employed in preoperative gamma detection imaging in combination with various other techniques, including scintigraphy, SPECT, and SPECT/CT4. It may be administered via subcutaneous, intradermal, subareolar, or peritumoral injection, depending on the tutor location and planned injection techniqueLabel. It is marketed under the trade name Lymphoseek. Potential application of technetium Tc-99m tilmanocept to other cancers are being investigated3. IntroductionInterferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Type I interferons also induce the synthesis of several key antiviral mediators including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R. Application1Squamous Cell Carcinoma (SCC)Squamous Cell Carcinoma of the Oral CavityTumors, Solid Application2 Application3 警示图 危险性 危险性警示 warning 安全声明 安全防护 备注 实验过程中防止吸入、食如，做好安全防护 对不起，暂无产品评价！