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中文别名 KB 5492 英文别名 KB 5492; KB-5492; KB5492; CAS号 129200-10-8 SMILES O=C(OC1=CC=C(OC)C=C1)CN2CCN(CC3=CC(OC)=C(OC)C(OC)=C3)CC2.O=C(O)/C=C/C(O)=O Inchi InChI=1S/C23H30N2O6.C4H4O4/c1-27-18-5-7-19(8-6-18)31-22(26)16-25-11-9-24(10-12-25)15-17-13-20(28-2)23(30-4)21(14-17)29-3;5-3(6)1-2-4(7)8/h5-8,13-14H,9-12,15-16H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ InchiKey JUOYRBCKLAPYBI-WLHGVMLRSA-N 分子式 Formula C27H34N2O10 分子量 Molecular Weight 546.57 闪点 FP 熔点 Melting point 沸点 Boiling point Polarizability极化度 密度 Density 蒸汽压 Vapor Pressure 溶解度Solubility 性状 Solid powder 储藏条件 Storage conditions Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). 产品说明 KB 5492(CAS:129200-10-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 IntroductionKB 5492 is an anti-ulcer agent, preventing cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion. Application1 Application2 Application3 警示图 危险性 Warning 危险性警示 安全声明 安全防护 备注 [1]Shimohara K, Niida H, Okabe S. Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl) p iperazine monofumarate monohydrate, on gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1990 Jun;53(2):275-9. PubMed PMID: 2385012. [2]Harada Y, Hara H, Sukamoto T. Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa. Eur J Pharmacol. 1994 Aug 11;261(1-2):91-6. PubMed PMID: 8001658. [3] Harada Y, Hara H, Sukamoto T. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2;256(3):321-8. PubMed PMID: 8045277. [4] Morimoto Y, Shimohara K, Oshima S, Sukamoto T. Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Jpn J Pharmacol. 1991 Dec;57(4):495-505. PubMed PMID: 1803065. [5] Morimoto Y, Oshima S, Hara H, Sukamoto T. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan;64(1):41-7. PubMed PMID: 8164392. 6: Morimoto Y, Shimohara K, Tanaka K, Hara H, Sukamoto T. 4-Methoxyphenyl 4-(3,4,5-trimethoxybenzyl)-1-piperazineacetate monofumarate monohydrate (KB-5492), a new anti-ulcer agent with a selective affinity for the sigma receptor, prevents cysteamine-induced duodenal ulcers in rats by a mechanism different from that of cimetidine. Jpn J Pharmacol. 1994 Mar;64(3):221-4. PubMed PMID: 8022123.7: Hara H, Tanaka K, Harada Y, Sukamoto T. Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805. PubMed PMID: 8182548.8: Morimoto Y, Shimohara K, Oshima S, Hara H, Sukamoto T. Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier. Jpn J Pharmacol. 1994 Jan;64(1):49-55. PubMed PMID: 8164393. 对不起，暂无产品评价！