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中文别名 L-771688 dihydrochloride 英文别名 L-771688 dihydrochloride; L 771688 dihydrochloride; L771688 dihydrochloride; CAS号 200051-19-0 SMILES COCC1=C(C(OC)=O)[C@H](c2cc(F)c(F)cc2)N(C(N1)=O)C(NCCCN3CCC(c4ncccc4)CC3)=O.Cl.Cl Inchi InChI=1S/C28H33F2N5O5.2ClH/c1-39-17-23-24(26(36)40-2)25(19-7-8-20(29)21(30)16-19)35(28(38)33-23)27(37)32-12-5-13-34-14-9-18(10-15-34)22-6-3-4-11-31-22;;/h3-4,6-8,11,16,18,25H,5,9-10,12-15,17H2,1-2H3,(H,32,37)(H,33,38);2*1H/t25-;;/m0../s1 InchiKey ZMUWSPDVFPVYFA-WLOLSGMKSA-N 分子式 Formula C28H35Cl2F2N5O5 分子量 Molecular Weight 630.51 闪点 FP 熔点 Melting point 沸点 Boiling point Polarizability极化度 密度 Density 蒸汽压 Vapor Pressure 溶解度Solubility 性状 Solid powder 储藏条件 Storage conditions Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). 产品说明 L-771688 dihydrochloride(CAS:200051-19-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 IntroductionL-771688, also known as SNAP-6383, is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia. L-771,688 had high affinity (Ki less than or = 1 nM) for [3H]prazosin binding to cloned human, rat and dog alpha1A-adrenoceptors and high selectivity (>500-fold) over alpha1B and alpha1D-adrenoceptors. L-771,688 is a highly selective alpha1A-adrenoceptor antagonist. Application1 Application2 Application3 警示图 危险性 Warning 危险性警示 安全声明 安全防护 备注 [1]Xu F, Huang D, Lin X, Wang Y. Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids. Org Biomol Chem. 2012 Jun 14;10(22):4467-70. doi: 10.1039/c2ob25663k. Epub 2012 May 8. PubMed PMID: 22565820. [2]Li N, Chen XH, Song J, Luo SW, Fan W, Gong LZ. Highly enantioselective organocatalytic Biginelli and Biginelli-like condensations: reversal of the stereochemistry by tuning the 3,3'-disubstituents of phosphoric acids. J Am Chem Soc. 2009 Oct 28;131(42):15301-10. doi: 10.1021/ja905320q. Erratum in: J Am Chem Soc. 2010 Aug 11;132(31):10953. PubMed PMID: 19785440. [3] Winchell GA, Mistry GC, Kari PP, Marbury T, Miller JL, Simpson RC, Rodrigues AD, Gottesdiener KM, Wagner JA. The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. J Clin Pharmacol. 2005 Jun;45(6):699-703. PubMed PMID: 15901753. [4] Chang RS, Chen TB, O'Malley SS, Pettibone DJ, DiSalvo J, Francis B, Bock MG, Freidinger R, Nagarathnam D, Miao SW, Shen Q, Lagu B, Murali Dhar TG, Tyagarajan S, Marzabadi MR, Wong WC, Gluchowski C, Forray C. In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J Pharmacol. 2000 Dec 15;409(3):301-12. PubMed PMID: 11108825. 对不起，暂无产品评价！