【产品介绍】：

中文别名 GL-V9 英文别名 GL-V9; GLV9; GL V9 CAS号 1178583-19-1 SMILES O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=CC(OCCCCN4CCCC4)=C3OC Inchi InChI=1S/C24H27NO5/c1-28-23-21(29-14-8-7-13-25-11-5-6-12-25)16-19(27)22-18(26)15-20(30-24(22)23)17-9-3-2-4-10-17/h2-4,9-10,15-16,27H,5-8,11-14H2,1H3 InchiKey UTBSFLRYDHWNGC-UHFFFAOYSA-N 分子式 Formula C24H27NO5 分子量 Molecular Weight 409.48 闪点 FP 熔点 Melting point 沸点 Boiling point Polarizability极化度 密度 Density 蒸汽压 Vapor Pressure 溶解度Solubility 性状 Solid powder 储藏条件 Storage conditions Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). 产品说明 GL-V9(CAS:1178583-19-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 IntroductionGL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. Application1 Application2 Application3 警示图 危险性 Warning 危险性警示 安全声明 安全防护 备注 [1]Yang L, He Z, Yao J, Tan R, Zhu Y, Li Z, Guo Q, Wei L. Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells. Redox Biol. 2018 Jul;17:180-19[1]doi: 10.1016/j.redox.2018.04.016. Epub 2018 Apr 18. PubMed PMID: 29702405; PubMed Central PMCID: PMC6006728. [2]Zhao Y, Guo Q, Zhao K, Zhou Y, Li W, Pan C, Qiang L, Li Z, Lu N. Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. Oncoimmunology. 2017 Sep 21;7(1):e1375640. doi: 10.1080/2162402X.2017.1375640. eCollection 2017. PubMed PMID: 29296531; PubMed Central PMCID: PMC5739552. [3] Zhang X, Kang Y, Huo T, Tao R, Wang X, Li Z, Guo Q, Zhao L. GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells. Free Radic Biol Med. 2017 Nov;11 2:49-59. doi: 10.1016/j.freeradbiomed.2017.07.011. Epub 2017 Jul 9. PubMed PMID: 28697922. [5] Zhao K, Li G, Yao Y, Zhou Y, Li Z, Guo Q, Lu N. Activation of phospholipase C-γ1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells. Exp Cell Res. 2017 Jul 1;356(1):8-19. doi: 10.1016/j.yexcr.2017.03.063. Epub 2017 Apr 13. PubMed PMID: 28412247. 对不起，暂无产品评价！