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中文别名 英文别名 PD 134922 CAS号 150351-30-7 SMILES O=C(NCCCC)[C@H](C(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC([C@H](CC=C)NC([C@H](Cc2ccccc2)NS(N3CCOCC3)(=O)=O)=O)=O Inchi InchiKey 分子式 Formula C37H61N5O7S 分子量 Molecular Weight 719.9745 闪点 FP 熔点 Melting point 沸点 Boiling point Polarizability极化度 密度 Density 蒸汽压 Vapor Pressure 溶解度Solubility 性状 储藏条件 Storage conditions Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). 产品说明 (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropyl-5-((S)-2-((S)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)pent-4-enamido)hexanamide(CAS:150351-30-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 IntroductionPD 134922 is a novel HIV-1 protease inhibitors identified by rational selection.The human immunodeficiency virus (HIV-1), associated with the AIDS (acquired immunodeficiency syndrome) epidemic, encodes an aspartyl protease that is essential for polyprotein processing in the virus (Navia et al., 1989). It has been demonstrated that inactivation of the protease either catalytically or by an inhibitor prevents infectious virion formation (Kohl et al., 1988; Darke et al., 1989). The acquired knowledge of key molecular interactions occurring between inhibitors and aspartyl proteases, as well as the structural similarities between HIV-1 protease and human renin was used to rationally select candidates for HIV-1 screening from the pool of analogs designed as renin inhibitors. A minimal number of chosen compounds were tested in an HIV-1 protease assay system. Two structurally novel peptides emerged as potent enzymatic protease inhibitors. Application1 Application2 Application3 警示图 危险性 Warning 危险性警示 安全声明 安全防护 备注 对不起，暂无产品评价！