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CAS:124750-99-8|氯沙坦钾

发布时间:2022-04-02     作者:德尔塔   分享到:

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产品名称 氯沙坦钾 英文名称 Losartan Potassium (DuP 753) 应用 A specific antagonist of the AT1 receptor with significant downstream effects. 规格或纯度 ≥99% 别名 洛沙坦钾;2-丁基-4-氯-1-[[2'-(1H-四唑-5-基)-1,1'-联苯-4-基]甲基]咪唑-5-甲醇钾;2-丁基-4-氯-1-{[2′-(1H-四唑-5-基)(1,1′-联苯)-4-基]甲基}-1H-咪唑-5-甲醇 单钾盐 英文别名 DuP-753 potassium; Cozaar potassium;Losartan potassium salt;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt 运输条件 常规运输 生化机理 Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARγ) activity.Selective non-peptide angiotensin II type 1 (AT 1 ) receptor antagonist (K i = 10 nM). Blocks classical actions of angiotensin II . Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo .CAS编号 124750-99-8 敏感性 对湿度敏感 熔点 183.5 - 184.5 °C 溶解性 Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (100 mM), and DMF (≥20 mg/ml). Reaxys-RN 5900704 RTECS NI6755100 MDL号 MFCD02092704 分子量 461 分子式 C22H22ClKN6O PubChem CID 11751549