【产品介绍】：

产品名称 伊马替尼甲磺酸盐 英文名称 Imatinib Mesylate (STI571) 应用 A c-Abl, PDGFR, and c-kit inhibitor 规格或纯度 ≥99% 别名 甲磺酸伊马替尼 英文别名 CGP 57148;Genfatinib;Glivec;STI-571;Imatinib methanesulfonate;4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate;4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyri 运输条件 冰袋运输 生化机理 Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit.Potent, selective inhibitor of tyrosine kinases v-Abl (IC 50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukCAS编号 220127-57-1 溶解性 Soluble in water (200 mg/ml), ethanol (~0.2 mg/ml), DMSO (200 mg/ml), DMF (~10 mg/ml), and methanol (sparingly). 储存温度 2-8°C储存 MDL号 MFCD04307699 分子量 589.71 分子式 C29H31N7O.CH4SO3 PubChem CID 123596