【产品介绍】：

产品名称 FH535 英文名称 FH535 应用 A cell-permeable compound that inhibits Wnt/β-catenin and PPAR 规格或纯度 ≥98% 别名 FH 535;FH-535 英文别名 FH 535;FH-535；2,5-dichloro-n-(2-methyl-4-nitrophenyl)benzenesulfonamide；N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide 运输条件 冰袋运输 生化机理 Description:IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1] FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand-dependent activation and shows structural similarity to GW9662, a known PPAR gamma antagonist.in vitro:  FH535 significantly inhibited cell migration of Mel 1241 cells, which was associated with the elevated levels of casein kinase 1α and glycogen synthase kinase-3β, and decreased accumulation of nuclear β-catenin and inhibition of MMP-2 and MMP-9 levels [2].  FH535 was shown to increase CSC-induced cytotoxicity and depress β-catenin expression. However, FH535 effects were not limited to the β-catenin pathway as it also blocked the expression of early growth responsive protein 1 (EGR-1) target genes, fibronectin and phosphatase and tensin homologue, without affecti.Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro . Antitumor agent.CAS编号 108409-83-2 折光率 1.65 熔点 202.89°C 沸点 ~526.3° C at 760 mmHg 溶解性 25°C: DMSO 储存温度 2-8°C储存 密度 1.6 分子量 361.2 分子式 C13H10Cl2N2O4S PubChem CID 3463933