【产品介绍】：

产品名称 孟鲁司特钠 水合物 英文名称 Montelukast sodium hydrate 应用 Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist. 规格或纯度 ≥99% 别名 孟鲁司特钠 水合物 英文别名 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate 运输条件 冰袋运输 生化机理 Montelukast Sodium(Singulair) is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium (Singulair) has demonstrated the ability to increase PGE2 production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.Potent, selective leukotriene D4 antagonist (K i = 0.18 nM). Specific CysLT1 receptor antagonist. Shows anti-inflammatory and anti-Asthmatic effects. Orally active. Active in vitro and in vivo .CAS编号 151767-02-1 敏感性 对湿度敏感;对空气敏感;对光线敏感 比旋光度 +95.0 to +105.0 deg(C=1、MeOH) 熔点 115 °C(dec.) 溶解性 DMSO 100 mg/mL Water 100 mg/mL Ethanol 100 mg/mL 储存温度 2-8°C储存 Reaxys-RN 7617467 RTECS GZ0698000 MDL号 MFCD00931431 分子量 608.17 (anhydrous basis) 分子式 C35H35ClNO3S·Na · xH2O 替代CAS 158966-92-8 PubChem CID 23663996