【产品介绍】：

产品名称 Tenovin-1 英文名称 Tenovin-1 应用 An inhibitor of SIRT1 and SIRT2. 规格或纯度 ≥98% 别名 Tenovin 1 英文别名 Tenovin 1;N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide 运输条件 超低温冰袋运输 生化机理 Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6. Tenovin-1 is an activator of p21 and p53.p53 Activator. Protects p53 from MDM2 mediated degradation through SirT1 inhibition. Inhibits downstream histone acetylation, activates p21CIP/WAF1. Potent antiproliferative effects in vitro .CAS编号 380315-80-0 溶解性 Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml). 储存温度 -20°C储存 分子量 369.48 分子式 C20H23N3O2S PubChem CID 1013376