【产品介绍】：

产品名称 Deltarasin 英文名称 Deltarasin 生化机理 Description:IC50 Value: 41±12 nM (binding to PDEδ in cell) [1]Deltarasin is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction and impairs oncogenic KRAS signalling.Interfering with binding of mammalian PDEδ to KRAS by means of small molecules provides a novel opportunity to suppress oncogenic RAS signalling by altering its localization to endomembranes. Biochemical screening and subsequent structure-based hit optimization yielded inhibitors of the KRAS-PDEδ interaction that selectively bind to the prenyl-binding pocket of PDEδ with nanomolar affinity, inhibit oncogenic RAS signalling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.CAS编号 1440898-61-2 溶解性 DMSO 储存温度 储存温度-20°C 分子量 603.75 分子式 C40H37N5O PubChem CID 73292904