【产品介绍】：

中文别名 英文别名 Nephrin CAS号 65136-96-1 SMILES CC1(C)CCC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5(C)CC[C@H](C(C)(O)C)[C@@]([H])5CC[C@](C)4[C@@](C)3[C@@H](O)[C@H](O)C12 Inchi InchiKey 分子式 Formula C30H52O3 分子量 Molecular Weight 460.74 闪点 FP 熔点 Melting point 沸点 Boiling point Polarizability极化度 密度 Density 蒸汽压 Vapor Pressure 溶解度Solubility 性状 储藏条件 Storage conditions Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). 产品说明 Hopane-6alpha,7beta,22-triol(CAS:65136-96-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 IntroductionNephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highly conserved proteins with a well characterized function as modulators of cell adhesion and guidance, and nephrin may have a role in metabolic pathways linked to podocyte and pancreatic β-cell survival. Nephrin is associated and partly co-localized with PI3-kinase in mouse islet β-cells and the mouse pancreatic beta-cell line (βTC-6 cells). Nephrin silencing abolishes Akt activation and increased susceptibility of cells to apoptosis. Glucose-induced changes in nephrin signaling may contribute to gradual pancreatic β-cell loss in type 2 diabetes. This suggests a role for nephrin as an independent modulator of podocyte and pancreatic β-cell nutrient sensing in the fasting state and the potential of nephrin as a drug target in diabetes. Application1 Application2 Application3 警示图 危险性 Warning 危险性警示 安全声明 安全防护 备注 对不起，暂无产品评价！