【产品介绍】：

产品名称 AZD1480 英文名称 AZD1480 应用 An inhibitor of JAK2 规格或纯度 ≥98% 别名 AZD1480;AZD 1480 英文别名 AZD1480;AZD 1480；5-chloro-n2-((1s)-1-(5-fluoro-2-pyrimidinyl)ethyl)-n4-(5-methyl-1h-pyrazol-3-yl)-2,4-pyrimidinediamine；(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine 运输条件 超低温冰袋运输 生化机理 AZD1480 demonstrated significant immunoregulatory effects by downregulating T-helper 2 cytokines and chemokines, including IL-13 and thymus- and activation-regulated chemokine, and the surface expression of the immunosuppressive programmed death ligands 1 and 2. Higher concentrations of AZD1480 (5μ) induced G2/M arrest and cell death by inhibiting Aurora kinases.Novel, potent and selective small-molecule JAK2 inhibitor (IC 50 < 3 nM). \xa0It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3CAS编号 935666-88-9 折光率 1.7 熔点 213.39°C 沸点 ~575.2 °C at 760 mmHg 溶解性 DMSO ≥68mg/mL Water <1.2mg/mL Ethanol ≥4.7mg/mL 储存温度 -20°C储存 密度 1.5 分子量 348.77 分子式 C14H14ClFN8 PubChem CID 16659841