【产品介绍】：

产品名称 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮 英文名称 Apoptosis Activator 2 应用 An indoledione caspase activator 规格或纯度 ≥98% 别名 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione 英文别名 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione 运输条件 冰袋运输 生化机理 Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.Cell-permeable cytochrome c caspase activator. Promoting cytochrome-c dependent oligomerization of Apaf-1 into the mature apoptosome. Induces apoptosis in tumor cells (IC 50 = ~4 µM).CAS编号 79183-19-0 敏感性 对光敏感 溶解性 Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.; DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 储存温度 2-8°C储存 分子量 306.14 分子式 C15H9Cl2NO2 PubChem CID 1901244