【产品介绍】：

产品名称 PF-3084014 英文名称 PF-3084014 规格或纯度 ≥98% 生化机理 Description:IC50 Value: 1.2 nM (whole-cell assay);6.2 nM (cell-free assay) [1]PF-03084014 is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro IC(50) of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay).in vitro: PF-03084014 inhibits Notch-related T- and B-cell maturation in an in vitro thymocyte assay with an EC(50) of 2.1 microM. A single acute dose showed dose-dependent reduction in brain, cerebrospinal fluid (CSF), and plasma Abeta in Tg2576 mice as measured by enzyme-linked immunosorbent assay and immunoprecipitation (IP)/mass spectrometry (MS) [1]. The ability of PF-03084014 to inhibit gamma-secretase activity was shown by the reduction of endogenous NICD levels and by the downregulation of Notch target genes Hes-1 and cMyc in the T-cell acute lymphoblastic leukemia (T-ALL) cell line HPB-ALL. PF-03084014 caused cell growth inhibition of several T-ALL cell lines via cell cycle arrest and inductionCAS编号 1290543-63-3 溶解性 25°C: DMSO 储存温度 储存温度-20°C 分子量 489.64 分子式 C27H41F2N5O PubChem CID 46224413