【产品介绍】：

产品名称 烟曲霉素 英文名称 Fumagillin 应用 An angiogenesis suppressing antibiotic and MetAP-2 inhibitor.It is an effective treatment for intestinal microsporidiosis caused by Enterocytozoon bieneusi. Used to treat the Nosema disease in honey bees. Applied topically to the conjunctiva in the treatment of microsporidial keratoconjunctivitis. The Research grade Fumagillin is used in the angiogenesis research. In the connection to its anti angiogenetic capabilities, Fumagillin is mentioned as an potential anti-neoplastic antibiotic;Fumagillin is a starting material for several anticancer drug candidates, such as TNP-470, also shown to be able to protect macrophages from the HIV infection 规格或纯度 98% 别名 Fumagillin 英文别名 (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester 运输条件 超低温冰袋运输 生化机理 Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP 2 ) (IC 50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesity in vivo . Orally active.CAS编号 23110-15-8 敏感性 对光和空气敏感 溶解性 Soluble in DMSO (25 mg/ml), ethanol (1 mg/ml), and methanol (slightly soluble). Insoluble in water. 储存温度 -20°C储存,充氩 RTECS HE1750000 MDL号 MFCD03990453 分子量 458.54 分子式 C26H34O7 EC号 245-433-8 PubChem CID 6917655