【产品介绍】：

产品名称 CGK 733 英文名称 CGK 733 应用 A cell-permeable compound that inhibits kinase activity of ATM / ATR (RETRACTED). 规格或纯度 ≥99% 别名 CGK-733;ATM/ATR Kinase Inhibitor;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide 英文别名 CGK-733;ATM/ATR Kinase Inhibitor;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide 运输条件 冰袋运输 生化机理 ATM/ATR Kinase Inhibitor (CGK733) Was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC50 ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product we retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated.Selective ATR and ATM kinase inhibitor. Shows antiproliferative effects in a range of cancer cell lines. Blocks recruitment and hyperphosphorylation of RPA2.CAS编号 905973-89-9 溶解性 DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 储存温度 2-8°C储存 分子量 555.84 分子式 C23H18Cl3FN4O3S