【产品介绍】：

产品名称 VE-821 英文名称 VE-821 规格或纯度 ≥98% 别名 VE821;VE 821 英文别名 VE821;VE 821;3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide ; 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide 运输条件 超低温冰袋运输 生化机理 VE-821 is a novel ATR inhibitor. VE-821, sensitises tumour cells to DNA damage induced by radiation or chemotoxic drμgs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.Potent, selective ATP competitive ATR inhibitor (K i\xa0= 13 nM). Exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro . Decreases phosphorylation of Chk1 and increases sensitivity of pancreatic cancer cellsCAS编号 1232410-49-9 溶解性 DMSO 74 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 储存温度 -20°C储存 分子量 368.41 分子式 C18H16N4O3S PubChem CID 51000408