【产品介绍】：

产品名称 Doramapimod 英文名称 Doramapimod 应用 A p38α MAPK and JNK2 规格或纯度 ≥99% 别名 BIRB 796;BIRB796 英文别名 BIRB 796;BIRB-796;BIRB796;1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea; 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 运输条件 超低温冰袋运输 生化机理 Doramapimod is a highly selective p38α MAPK inhibitor to TNF-α with EC50 of 18 nM. At 10 μM, doramapimod inhibits JNK2 in vitro, but at the low concentration necessary to inhibit p38α, it does not affect the phosphorylation of JNK substrates in cells.Potent, selective, cell permeable\xa0p38 MAPK inhibitor (IC 50 values of 38\xa0nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; K d for p38α = 0.1 nM). Anti-inflammatory activity in vivo .CAS编号 285983-48-4 溶解性 Soluble in DMSO (~25 mg/ml), water (poorly soluble), ethanol (~3 mg/ml), and DMF (~25 mg/ml). 储存温度 -20°C储存 分子量 527.67 分子式 C31H37N5O3 PubChem CID 156422