【产品介绍】：

产品名称 ZM 336372 英文名称 ZM 336372 应用 A potent and selective Raf-1 inhibitor. 规格或纯度 ≥98% 别名 ZM-336372 英文别名 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide;ZM336372; ZM-336372 运输条件 冰袋运输 生化机理 ZM 336372 is a reversible, selective inhibitor of the protein kinase Raf-1 (IC50 = 70nM). Althoμgh ZM 336372 weakly inhibits Raf-B, it is 10 fold more potent against Raf-1 and so is considered more selective towards this kinase. ZM 336372 inhibits Raf-1 by competing with ATP to bind to the protein. Alternate studies sμggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β (GSK-3β) throμgh phosphorylation of GSK-3&beta at Ser 9. In addition, ZM 336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM 336372 can also act as an agonist towards Raf-1, activating the MAPK pathway, which can be suppressed after activation by Raf-1 itself, using a novel feedback loop in which activation is always followed by inactivation. ZM 336372 is an inhibitor of p38 α and p38 β.Potent, cell-permeable and selective c-Raf inhibitor (IC 50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.CAS编号 208260-29-1 敏感性 对光敏感 溶解性 Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C). 储存温度 2-8°C储存 MDL号 MFCD02683971 分子量 389.45 分子式 C23H23N3O3 PubChem CID 5730