【产品介绍】：

产品名称 Raloxifene HCl 英文名称 Raloxifene HCl 应用 A SERM of ERα and ERβ. 规格或纯度 ≥98% 别名 盐酸雷洛昔芬 英文别名 Raloxifene Hydrochloride;keoxifene;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride 运输条件 超低温冰袋运输 生化机理 Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor.Selective estrogen receptor modulator (SERM). Binds to both ER α (K d = 90pM) and ER β . Tissue-dependently inhibits or activates ER-induced transcription. Inhibits estradiol-induced progesterone receptor activity in hypothalamic cells (IC 50 = 1nM).CAS编号 82640-04-8 溶解性 Soluble in DMSO (50 mM), methanol, and ethanol (<1 mg/ml at 25 °C). Insoluble in water. 储存温度 -20°C储存 分子量 510.04 分子式 C28H27NO4S·HCl PubChem CID 54900