【产品介绍】：

产品名称 IOX2 英文名称 IOX2 规格或纯度 ≥98% 别名 IOX 2;IOX-2;JICL38 英文别名 IOX 2;IOX-2;JICL38; N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine; N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine 运输条件 冰袋运输 生化机理 IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R throμgh inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish.Potent, cell-permeable, selective HIF-1 α prolyl hydroxylase-2 (PHD2) inhibitor (IC 50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.CAS编号 931398-72-0 溶解性 DMSO 100 mg/ml 储存温度 2-8°C储存 分子量 352.34 分子式 C19H16N2O5 PubChem CID 54685215