【产品介绍】：

产品名称 Fostamatinib (R788) 英文名称 Fostamatinib (R788) 应用 An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling 规格或纯度 ≥98% 别名 R788 英文别名 (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate;R 788; R-788 运输条件 干冰运输 生化机理 R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, sμggesting that they are antigen driven.CAS编号 901119-35-5 溶解性 DMSO 116 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 储存温度 −20°C 分子量 580.46 分子式 C23H26FN6O9P PubChem CID 11671467