【产品介绍】：

产品名称 TAE684(NVP-TAE684) 英文名称 TAE684 (NVP-TAE684) 应用 A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase 规格或纯度 ≥98% 别名 NVP-TAE684 英文别名 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; NVP-TAE684 运输条件 超低温冰袋运输 生化机理 TAE684 selectively inhibits the phosphorylation of NPM-ALK, inducing apoptosis and G1 phase arrest in Ba/F3 cell lines. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation of NPM-ALK-expressing human ALCL cell lines including Karpas-299 and SU-DHL-1 with IC50 of 2–5 nM.Highly potent, selective ALK inhibitor in vitro (IC 50 = 2 nM). Suppresses lymphomagenesis in vivo . Down-regulates CD30 expression. Antitumor agent. Potent LRRK2 kinase inhibitor (IC 50 = 7.8 nM).CAS编号 761439-42-3 溶解性 DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 储存温度 -20°C储存 分子量 614.2 分子式 C30H40ClN7O3S PubChem CID 16038120