【产品介绍】：

产品名称 Lenvatinib Mesylate 英文名称 lenvatinib Mesylate 规格或纯度 99% 别名 甲磺酸乐伐替尼 英文别名 E7080；4-3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy-7-methoxy-6-quinolinecarboxamide mesylate； 4-3-chloro-4-(cyclopropylamino)carbonylaminophenoxy-7-methoxy-6-Quinolinecarboxamide methanesulfonate (1:1)； 4-3-Chloro-4-(N’-cyclopropylureido)phenoxy-7- 运输条件 冰袋运输 生化机理 Lenvatinib (E7080) is an orally active inhibitor against multiple receptor tyrosine kinases, including VEGFR (Flt-1/KDR/Flt-4 IC50 = 22/4.0/5.2 nM), PDGFR1/2 (IC50 = 39/51 nM), FGFR1 and KIT (IC50 = 46 and 100 nM, respectively) that inhibits angiogenesis in vitro (VEGF/SCF-induced HUVEC tube formation IC50 = 5.1/5.2 nM). Lenvatinib oral administration results in tumor growth arrest (30 mg/kg b.i.d. p.o.) and even regression (100 mg/kg b.i.d. p.o.) in vivo among mice harboring SCF-producing human small cell lung carcinoma H146 cells.CAS编号 857890-39-2 储存温度 2-8°C储存,干燥 分子量 522.96 分子式 C21H19N4O4Cl.CH4O3S