【产品介绍】：

产品名称 PNU 74654 英文名称 PNU 74654 规格或纯度 ≥98% 别名 2-苯氧基苯甲酸[（5-甲基-2-呋喃基）亚甲基]酰肼；苯甲酸，2-苯氧基-，2-[（5-甲基-2-呋喃基）亚甲基]酰胺 英文别名 2-Phenoxybenzoicacid[(5-methyl-2-furanyl)methylene]hydrazide；(E)-N'-((5-methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide 运输条件 超低温冰袋运输 生化机理 Wnt信号通路阻滞剂。抑制Wnt /β-catenin途径。阻止β-catenin和TCF之间的蛋白质相互作用。抗肿瘤作用。PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.CAS编号 113906-27-7 溶解性 Soluble in DMSO to 75 mM 储存温度 -20°C储存,干燥 分子量 320.34 分子式 C19H16N2O3 PubChem CID 9836739