【产品介绍】：

产品名称 PF-573228 英文名称 PF-573228 应用 A potent and selective FAK (focal adhesion kinase) inhibitor. 规格或纯度 ≥98% 别名 PF 573228 英文别名 PF573228;PF 573228;6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one; PF-228;FAK Inhibitor II 运输条件 冰袋运输 生化机理 PF 573228 is a potent and selective FAK (focal adhesion kinase) inhibitor (IC50 = 4 nM). PF 573228 displays 50-250-fold selectivity over other protein kinases. PF 573228 decreases focal adhesion kinase (FAK) turnover in vitro. PF 573228 also blocks serum and fibronectin-directed migration.Potent and selective FAK inhibitor (IC 50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells\xa0(IC 50 = 30–100 n M). Shows\xa050 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. 法律信息 Sold for only research purposesCAS编号 869288-64-2 溶解性 Soluble in DMSO (≥20 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). 储存温度 2-8°C储存 MDL号 MFCD11519967 分子量 491.49 分子式 C22H20F3N5O3S PubChem CID 11612883