【产品介绍】：

产品名称 TIC10 Analogue 英文名称 TIC10 Analogue 应用 A small molecule that induces TRAIL in a p53-independent manner 规格或纯度 ≥98% 别名 ONC201, NSC 350625 英文别名 TRAIL-inducing Compound 10;TIC10 isomer;ONC201 isomer;2,6,7,8,9,10-Hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one;7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin- 运输条件 超低温冰袋运输 生化机理 TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent.TRAIL activator. Induces TRAIL via Akt and ERK inactivation. Induces apoptosis in cancer cells and healthy cells. Shows antitumor effects in vivo. Blood-brain barrier permeable.CAS编号 41276-02-2 溶解性 DMSO mg/mL Water mg/mL Ethanol mg/mL 储存温度 -20°C储存 分子量 386.49 分子式 C24H26N4O PubChem CID 336423