【产品介绍】：

产品名称 GSK343 英文名称 GSK343 应用 An inhibitor of the histone lysine methyltransferase ENX-1.It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). 规格或纯度 ≥98% 别名 1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺 英文别名 N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide 运输条件 冰袋运输 生化机理 It is a potent, specific inhibitor of the histone H3-lysine 27 (H3K27) methyltransferase EZH2. GSK343 inhibits EZH2 enzymatic activity with an IC50 of 4 nM. The compound displays 60 fold selectivity for EZH2 vs. EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. The IC50 for inhibition of H3K27 methylation is < 200 nM in HCC1806 cells.Potent,\xa0selective, cell-permeable histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor.\xa0 Inhibits EZH2 enzymatic activity (IC 50\xa0= 4 nM).CAS编号 1346704-33-3 溶解性 DMSO: soluble15 mg/mL, clear 储存温度 2-8°C储存 分子量 541.69 分子式 C31H39N7O2 PubChem CID 71268957