【产品介绍】：

产品名称 RG7112 英文名称 RG7112 规格或纯度 ≥98% 运输条件 超低温冰袋运输 生化机理 Restoration of p53 activity by inhibiting the p53-MDM2 interaction may represent a novel approach to cancer treatment. RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. In cancer cells expressing wild-type p53, RG7112 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts.Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor proteCAS编号 939981-39-2 溶解性 DMSO 储存温度 -20°C储存 分子量 727.78 分子式 C38H48Cl2N4O4S PubChem CID 57406853