【产品介绍】：

产品名称 ABT-737 英文名称 ABT-737 应用 A selective inhibitor of Bcl-2 规格或纯度 ≥97% 别名 ABT737;ABT 737 英文别名 ABT737;ABT 737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4- (dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl] sulfonylbenzamide 运输条件 超低温冰袋运输 生化机理 ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells.BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor. Triggers Bax/Bak-mediated apoptosis (EC 50 values are 79, 30 and 198 nM for Bcl-xL, Bcl-2 and Bcl-w mediated apoptosis respectively). Shows antitumor effects in vivo.CAS编号 852808-04-9 折光率 1.7 熔点 148-151°C 溶解性 DMSO ≥160mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 储存温度 -20°C储存 分子量 813.43 分子式 C42H45ClN6O5S2 PubChem CID 11228183